Symptoms of monkeypox usually appear three weeks after exposure to the virus. Symptoms of monkeypox vary by individual and can be mild to severe. Symptoms of monkeypox may include a rash that looks like pimples or blisters, headache, fatigue, fever, sore throat, nasal congestion, cough, chills, muscle aches, backache, and swollen lymph nodes. The rash may appear on the genitals, anus, mouth, face, chest, and hands. The pimples or blisters may be painful and itchy. The rash progresses to scabs before healing. Individuals with monkeypox remain contagious to others until all the scabs have completely healed, usually within two-to-four weeks.