Monoclonal Gammopathy of Undetermined Significance (MGUS) Overview

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Learn About Monoclonal Gammopathy of Undetermined Significance (MGUS)

What is the definition of Monoclonal Gammopathy of Undetermined Significance (MGUS)?
Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein called monoclonal protein is detected in the blood. MGUS typically does not cause any problems, although some affected people may experience numbness, tingling or weakness. In some cases, MGUS may progress over time to certain forms of blood cancer (such as multiple myeloma, macroglobulinemia, or B-cell lymphoma). MGUS is thought to be a multifactorial condition that is likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. People with MGUS are usually monitored closely to ensure that the levels of monoclonal protein do not rise and other problems do not develop.
What are the alternative names for Monoclonal Gammopathy of Undetermined Significance (MGUS)?
  • Monoclonal gammopathy of undetermined significance
  • MGUS
Who are the top Monoclonal Gammopathy of Undetermined Significance (MGUS) Local Doctors?
Demet G. Yasar
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Demet G. Yasar
Hematology
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Demet G. Yasar
Hematology

Vince Lombardi Cancer Clinic

2845 Greenbrier Rd, Ste 250, 
Green Bay, WI 
920-288-4180
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Demet Yasar is a Hematologist in Green Bay, Wisconsin. Dr. Yasar is rated as a Distinguished provider by MediFind in the treatment of Monoclonal Gammopathy of Undetermined Significance (MGUS). Her top areas of expertise are Myelodysplastic Syndrome (MDS), Thrombocytopenia, ALK-Positive Non-Small Cell Lung Cancer, and Schnitzler Syndrome.

Asheesh Shipstone
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Asheesh Shipstone
Hematology | Oncology
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Asheesh Shipstone
Hematology | Oncology

Ballad Health Cancer Center

2202 North John B. Dennis Highway, Suite 100, 
Kingsport, TN 
423-578-8500
Languages Spoken:
English
See accepted insurances

. Dr. Shipstone is rated as a Distinguished provider by MediFind in the treatment of Monoclonal Gammopathy of Undetermined Significance (MGUS). His top areas of expertise are Adult Immune Thrombocytopenia, Colorectal Cancer, Hemangioma Thrombocytopenia Syndrome, and Thrombocytopenia.

 
 
 
 
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Taewoong Choi
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Taewoong Choi
Hematology Oncology | Hematology | Transplant Surgery
Distinguished in Monoclonal Gammopathy of Undetermined Significance (MGUS)
Dr. Taewoong Choi
Hematology Oncology | Hematology | Transplant Surgery

Duke Blood Cancer Center

2400 Pratt St, 
Durham, NC 
919-684-8964
Languages Spoken:
English, Korean
See accepted insurances
Accepting New Patients
Offers Telehealth

Taewoong Choi is a Hematologist Oncology specialist and a Hematologist in Durham, North Carolina. Dr. Choi is rated as a Distinguished provider by MediFind in the treatment of Monoclonal Gammopathy of Undetermined Significance (MGUS). His top areas of expertise are Multiple Myeloma, Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance (MGUS), Bone Marrow Transplant, and Bone Marrow Aspiration. Dr. Choi is currently accepting new patients.

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What are the latest Monoclonal Gammopathy of Undetermined Significance (MGUS) Clinical Trials?
GammaGA: Study of the Prevalence of Acid Sphingomyelinase Deficiency Disease (ASMD) and Gaucher Disease in Patients With Monoclonal Gammopathies and/or Multiple Myeloma
GammaGA: Study of the Prevalence of Acid Sphingomyelinase Deficiency Disease (ASMD) and Gaucher Disease in Patients With Monoclonal Gammopathies and/or Multiple Myeloma
Enrollment Status: Recruiting
Publish Date: December 09, 2025

Summary: The study of splenomegaly, and the follow-up of splenectomized patients, is one of the causes of referral of these patients to pediatric gastroenterology and oncohematology clinics, and adult internal medicine and hematology. The study and management of splenomegaly is well described among the different medical specialties to which these patients arrive. After the application of the different algo...

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Study of Precursor Hematological Malignancies to Assess the Relationship Between Molecular Events of Progression and Clinical Outcome
Study of Precursor Hematological Malignancies to Assess the Relationship Between Molecular Events of Progression and Clinical Outcome
Enrollment Status: Recruiting
Publish Date: December 01, 2025

Summary: Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood. Several alterations that occur repeatedly in certain types of blood cancers have already been identified, and these discoveries have led to the development of new drugs that target those alterations. More remain to be...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center