• Be able and willing to provide documented informed consent prior to the conduct of any study procedures;

• Be an adult male or non-pregnant female ≥ 18 years of age;

• Report baseline pain scores of \>65mm on a 100mm Visual Analog Scale (VAS) at screening;

• Have a documented diagnosis of symptomatic neuroma of at least one interdigital nerve in the foot which cannot be repaired to a distal nerve end;

• Must have the of the following:

‣ Pain with at least 3 of the following characteristics: burning, sharp, shooting, electric, parasthesias, numbness, cold intolerance;

⁃ Symptoms in a defined neural anatomic distribution

⁃ History of nerve injury or suspected nerve injury

• Must have at least 1:

⁃ Positive response to local anesthetic injection

⁃ US or MRI confirmation of neuroma

• Be candidates indicated for surgery to address a symptomatic neuroma;

• Have sufficient healthy soft tissue available to adequately cover the Axoguard® Nerve Cap;

• In the surgeon's opinion, be likely to achieve complete resection of the symptomatic neuroma and be able to undergo implantation with the Axoguard® Nerve Cap or complete the neurotomy procedure in the control group;

• Be willing and able to comply with all aspects of the treatment and evaluation schedule over a 12-month duration.