Learn About Neuralgia
Neuralgia is a sharp, shocking pain that follows the path of a nerve and is due to irritation or damage to the nerve.
Common neuralgias include:
- Postherpetic neuralgia (pain that continues after a bout of shingles)
- Trigeminal neuralgia (stabbing or electric-shock-like pain in parts of the face)
- Alcoholic neuropathy
- Peripheral neuropathy
Nerve pain; Painful neuropathy; Neuropathic pain
Causes of neuralgia include:
- Chemical irritation
- Chronic kidney disease
- Diabetes
- Infections, such as herpes zoster (shingles), HIV/AIDS, Lyme disease, and syphilis
- Chemotherapy medicines such as cisplatin, paclitaxel, or vincristine
- Porphyria (blood disorder)
- Pressure on nerves by nearby bones, ligaments, blood vessels, or tumors
- Trauma (including surgery)
- Underlying nervous system disorder (such as multiple sclerosis)
In many cases, the cause is unknown.
Postherpetic neuralgia and trigeminal neuralgia are the two most common forms of neuralgia. A related but less common neuralgia affects the glossopharyngeal nerve, which provides feeling to the throat.
Neuralgia is more common in older people, but it may occur at any age.
Symptoms may include any of the following:
- Increased sensitivity of the skin along the path of the damaged nerve, so that any touch or pressure is felt as pain
- Pain along the path of the nerve that is sharp or stabbing, in the same location each episode, comes and goes (intermittent) or is constant and burning, and may get worse when the area is moved
- Weakness or complete paralysis of muscles supplied by the same nerve
Treatment depends on the cause, location, and severity of the pain.
Medicines to control pain may include:
- Antidepressants
- Antiseizure medicines
- Over-the-counter or prescription pain medicines
- Pain medicines in the form of skin patches or creams
Other treatments may include:
- Shots with pain-relieving (anesthetic) medicines
- Nerve blocks
- Physical therapy (for some types of neuralgia, especially postherpetic neuralgia)
- Procedures to reduce feeling in the nerve (such as nerve ablation using radiofrequency, heat, balloon compression, or injection of chemicals)
- Surgery to take pressure off a nerve
- Alternative therapy, such as acupuncture or biofeedback
Procedures may not improve symptoms and can cause loss of feeling or abnormal sensations.
When other treatments fail, providers may try nerve or spinal cord stimulation. In rare cases, a procedure called motor cortex stimulation (MCS) is tried. An electrode is placed over part of a nerve, spinal cord, or brain and is hooked to a pulse generator under the skin. This changes how your nerves signal and it may reduce pain.
Nanna Finnerup practices in Aarhus N, Denmark. Ms. Finnerup is rated as an Elite expert by MediFind in the treatment of Neuralgia. Her top areas of expertise are Neuralgia, Acute Pain, Diabetic Neuropathy, Chronic Pain, and Mastectomy.
Ralf Baron practices in Kiel, Germany. Mr. Baron is rated as an Elite expert by MediFind in the treatment of Neuralgia. His top areas of expertise are Neuralgia, Chronic Pain, Complex Regional Pain Syndrome, Pancreaticoduodenectomy, and Pancreatectomy.
Srinivasa Raja is a Pain Medicine specialist and an Anesthesiologist in Baltimore, Maryland. Dr. Raja is rated as an Elite provider by MediFind in the treatment of Neuralgia. His top areas of expertise are Neuralgia, Chronic Pain, Acute Pain, and Complex Regional Pain Syndrome.
Most neuralgias are not life threatening and are not signs of other life-threatening disorders. For severe pain that does not improve, see a pain specialist so that you can explore all treatment options.
Most neuralgias respond to treatment. Attacks of pain usually come and go. But, attacks may become more frequent in some people as they get older.
Sometimes, the condition may improve on its own or disappear with time, even when the cause is not found.
Complications may include:
- Problems from surgery
- Disability caused by pain
- Side effects of medicines used to control pain
Contact your provider if:
- You develop shingles
- You have symptoms of neuralgia, especially if over-the-counter pain medicines do not relieve your pain
- You have severe pain (see a pain specialist)
Strict control of blood sugar may prevent nerve damage in people with diabetes. In the case of shingles, antiviral medicines and the herpes zoster virus vaccine may prevent neuralgia.
Summary: This research is being done to study a possible treatment for refractory pain due to small fiber neuropathy (iSFN). ST-503 is intended to deliver a modified copy of the gene which will ideally repress Nav1.7 tissue-related pain signals reaching the brain, which should reduce the refractory pain due to small fiber neuropathy (iSFN).
Summary: The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Published Date: June 13, 2024
Published By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Cohen SP. Pain. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.
Katirji B. Disorders of peripheral nerves. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 106.
Smith AG, Shy ME. Peripheral neuropathies. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.