Condition 101 About Neuralgia

What is the definition of Neuralgia?

Neuralgia is a sharp, shocking pain that follows the path of a nerve and is due to irritation or damage to the nerve.

Common neuralgias include:

  • Postherpetic neuralgia (pain that continues after a bout of shingles)
  • Trigeminal neuralgia (stabbing or electric-shock-like pain in parts of the face)
  • Alcoholic neuropathy
  • Peripheral neuropathy

What are the alternative names for Neuralgia?

Nerve pain; Painful neuropathy; Neuropathic pain

What are the causes for Neuralgia?

Causes of neuralgia include:

  • Chemical irritation
  • Chronic kidney disease
  • Diabetes
  • Infections, such as herpes zoster (shingles), HIV/AIDS, Lyme disease, and syphilis
  • Medicines such as cisplatin, paclitaxel, or vincristine
  • Porphyria (blood disorder)
  • Pressure on nerves by nearby bones, ligaments, blood vessels, or tumors
  • Trauma (including surgery)

In many cases, the cause is unknown.

Postherpetic neuralgia and trigeminal neuralgia are the two most common forms of neuralgia. A related but less common neuralgia affects the glossopharyngeal nerve, which provides feeling to the throat.

Neuralgia is more common in older people, but it may occur at any age.

What are the symptoms for Neuralgia?

Symptoms may include any of the following:

  • Increased sensitivity of the skin along the path of the damaged nerve, so that any touch or pressure is felt as pain
  • Pain along the path of the nerve that is sharp or stabbing, in the same location each episode, comes and goes (intermittent) or is constant and burning, and may get worse when the area is moved
  • Weakness or complete paralysis of muscles supplied by the same nerve

What are the current treatments for Neuralgia?

Treatment depends on the cause, location, and severity of the pain.

Medicines to control pain may include:

  • Antidepressants
  • Antiseizure drugs
  • Over-the-counter or prescription pain medicines
  • Pain medicines in the form of skin patches or creams

Other treatments may include:

  • Shots with pain-relieving (anesthetic) drugs
  • Nerve blocks
  • Physical therapy (for some types of neuralgia, especially postherpetic neuralgia)
  • Procedures to reduce feeling in the nerve (such as nerve ablation using radiofrequency, heat, balloon compression, or injection of chemicals)
  • Surgery to take pressure off a nerve
  • Alternative therapy, such as acupuncture or biofeedback

Procedures may not improve symptoms and can cause loss of feeling or abnormal sensations.

When other treatments fail, doctors may try nerve or spinal cord stimulation. In rare cases, a procedure called motor cortex stimulation (MCS) is tried. An electrode is placed over part of nerve, spinal cord, or brain and is hooked to a pulse generator under the skin. This changes how your nerves signal and it may reduce pain.

What is the outlook (prognosis) for Neuralgia?

Most neuralgias are not life threatening and are not signs of other life-threatening disorders. For severe pain that does not improve, see a pain specialist so that you can explore all treatment options.

Most neuralgias respond to treatment. Attacks of pain usually come and go. But, attacks may become more frequent in some people as they get older.

Sometimes, the condition may improve on its own or disappear with time, even when the cause is not found.

What are the possible complications for Neuralgia?

Complications may include:

  • Problems from surgery
  • Disability caused by pain
  • Side effects of drugs used to control pain
  • Dental procedures that aren't needed before neuralgia is diagnosed

When should I contact a medical professional for Neuralgia?

Contact your provider if:

  • You develop shingles
  • You have symptoms of neuralgia, especially if over-the-counter pain medicines do not relieve your pain
  • You have severe pain (see a pain specialist)

How do I prevent Neuralgia?

Strict control of blood sugar may prevent nerve damage in people with diabetes. In the case of shingles, antiviral drugs and the herpes zoster virus vaccine may prevent neuralgia.

Central

REFERENCES

Katirji B. Disorders of peripheral nerves. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 107.

Scadding JW, Koltzenburg M. Painful peripheral neuropathies. In: McMahon SB, Koltzenburg M, Tracey I, Turk DC, eds. Wall and Melzack's Textbook of Pain. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 65.

Smith G, Shy ME. Peripheral neuropathies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 392.

Latest Advances On Neuralgia

  • Condition: Central Neuropathic Pain
  • Journal: Medicine
  • Treatment Used: Burst Spinal Cord Stimulation
  • Number of Patients: 2
  • Published —
This case report describes two patients with central neuropathic pain.
  • Condition: Chronic Pain in elderly with Osteoarthritis
  • Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • Treatment Used: Transdermal Buprenorphine
  • Number of Patients: 60
  • Published —
The study researched the outcomes of transdermal buprenorphine for treating chronic pain in elderly with osteoarthritis.

Clinical Trials For Neuralgia

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 3
  • Intervention Type: Other, Drug
  • Participants: 136
  • Start Date: November 2021
National, Multicentre, Randomized, Double-blind, Double-dummy Phase III Clinical Trial to Evaluate the Efficacy and Safety of Praga Formulation in the Treatment of Neuropathic Pain
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 3
  • Intervention Type: Drug
  • Participants: 88
  • Start Date: October 20, 2021
A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia