Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist.

• The ability to comply with test directions, complete pre-operative task training, and provide informed consent.

• Age 18-80 years.

Locations
United States
Massachusetts
Massachusetts General Hospital, University of California San Francisco, University of Utah
RECRUITING
Boston
Contact Information
Primary
Kristina Simonyan, MD, PhD
simonyan_lab@meei.harvard.edu
617-573-6016
Time Frame
Start Date: 2022-06-21
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 120
Treatments
Experimental: Electrophysiological signal data collection
Patients diagnosed with dystonia or tremor who are recommended for DBS surgery. Electrophysiological data will be collected at the time of DBS surgery.
Authors
Robert M Richardson, John Rolston, Doris Wang
Sponsors
Collaborators: University of Iowa, UMass Memorial Health, Massachusetts General Hospital, University of Utah, University of California, San Francisco
Leads: Massachusetts Eye and Ear Infirmary

This content was sourced from clinicaltrials.gov