Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care
this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.
• Individuals who are diagnosed with Primary Ciliary Dyskinesia OR
• Individuals with abnormal PCD diagnostics (abnormal ciliary biopsy or PCD genetics) OR
• Individuals with unexplained bronchiectasis OR
• Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following):
‣ Neonatal respiratory distress
⁃ Organ laterality defects
⁃ Year-round cough starting in first year of life or bronchiectasis on chest CT
⁃ Year-round nasal congestion starting in first year of life or pansinusitis
⁃ Multiple ear infections in the first two years of life with sequelae (e.g. ear tubes, chronic effusion, abnormal audiological exam)
⁃ History of recurrent pneumonias (at least 2 in one year or more than 3 at any time)
• Ability to provide consent for participation in study by the participants or guardian
• Ability to perform the test
• Age \>= 2 years of age