Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:

• Age 18 years or older

• Diagnosis of Tourette Syndrome

• Moderate Tic Severity at baseline

Locations
United States
West Virginia
WVU RNI
RECRUITING
Morgantown
Contact Information
Primary
Jessica Frey, MD
Jessica.frey@hsc.wvu.edu
304-598-6127
Time Frame
Start Date: 2024-03-12
Estimated Completion Date: 2026-12-30
Participants
Target number of participants: 20
Treatments
Active_comparator: Active rTMS
Patients receiving active rTMS
Sham_comparator: Sham rTMS
Patients receiving sham rTMS
Sponsors
Leads: West Virginia University
Collaborators: Tourette Association of America, University of Florida

This content was sourced from clinicaltrials.gov