Phase 1 Clinical Trial for MR Guided Focused Ultrasound (FUS) Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD)
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD). TSFD is a type of dystonia that affects hand movements during specific tasks such as writing, playing instruments or typing, often causing involuntarily movements or cramping.
• Clinical diagnosis of moderate to severe TSFD with impact in their daily function or occupation function
• Patients who failed to response or had unsatisfactory response to the first treatment, such as Botulinum toxin treatment or DBS or refuse these alternative options
• Age greater than 21 and less than 75 years
• Subjects who are able and willing to give consent and able to attend all study visits,
• Documented chronic, symptoms for more than 6 months duration
• Pallidotomy is feasible based on evaluation of imaging studies
• Patient able to communicate sensations during the ExAblate TcMRgFUS treatment
• Two members of the medical team have agreed upon inclusion and exclusion criteria