Sporadic Degenerative Ataxia With Adult Onset: Natural History Study (SPORTAX-NHS)

Status: Recruiting
Location: See all (14) locations...
Study Type: Observational
SUMMARY

The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both groups including determination of the factors that predict the development of MSA-C vs. SAOA, and at which time after onset of ataxia, a reliable distinction between both disorders is possible. The planned study will also allow to collect blood samples and other biomaterials from patients with sporadic ataxia, which will be useful for future genetic and biomarker studies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: t
View:

• Progressive ataxia

• Disease onset after the age of 40 years

• Informative and negative family history (no similar disorders in first- and second-degree relatives; parents older than 50 years, or, if not alive, age at death of more than 50 years, no consanguinity of parents)

Locations
Other Locations
Austria
Department of Neurology, Medical University, Innsbruck
ACTIVE_NOT_RECRUITING
Innsbruck
Germany
Universitätsmedizin Berlin Charité
RECRUITING
Berlin
Department of Neurology, University of Bonn
RECRUITING
Bonn
Department of Neurology, University Clinic Essen, University of Duisburg-Essen
RECRUITING
Essen
Department of Neurology, University of Frankfurt
RECRUITING
Frankfurt
Hamburg UKE Abt. Neuropädiatrie
ACTIVE_NOT_RECRUITING
Hamburg
Otto-von-Guericke Universität Magdeburg
RECRUITING
Magdeburg
Friedrich-Baur-Institut an der Neurologischen Klinik
RECRUITING
München
Universitätsmedidzin Rostock - Klinik und Poliklinik für Neurologie
RECRUITING
Rostock
Dept. of Neurodegenerative Diseases Tübingen
RECRUITING
Tübingen
Italy
Department of Neuroscience, Federico II University Naples
RECRUITING
Naples
Universita cattolica del sacro cuore
ACTIVE_NOT_RECRUITING
Rome
Netherlands
Radboud University Medical Center, Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour
ACTIVE_NOT_RECRUITING
Nijmegen
Norway
Oslo University Hospital
RECRUITING
Oslo
Contact Information
Primary
Ilaria Anna Giordano, MD
ilaria_anna.giordano@ukb.uni-bonn.de
0049 228 287 15750
Time Frame
Start Date: 2010-04
Estimated Completion Date: 2030-12
Participants
Target number of participants: 300
Treatments
sporadic adult onset ataxia
SAOA denotes the non-hereditary degenerative adult-onset ataxia disorders that are distinct from multiple system atrophy (MSA). SAOA is a group of ataxia of unknown etiology characterized by a slowly progressive cerebellar syndrome starting around the age of 50 years. Possibly is accompanied by signs of mild autonomic dysfunction that do not meet the criteria of severe autonomic failure required for a diagnosis of MSA.
cerebellar multiple system atrophy
Multiple system atrophy of cerebellar type is a cerebellar syndrome with sporadic onset developing in midlife, with autonomic features of otherwise unexplained bladder dysfunction with or without erectile dysfunction in males, orthostatic hypotension and atrophy of the cerebellum, brainstem, and middle cerebellar peduncles.
Sponsors
Collaborators: German Center for Neurodegenerative Diseases (DZNE)
Leads: Ataxia Study Group

This content was sourced from clinicaltrials.gov