Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
The goal of this clinical trial is to explore the effects of cerebellar nuclei TIS stimulation on improving tremor and gait disorders in PD patients. Through randomized double-blind grouping, the differences in efficacy between TIS intervention and sham stimulation intervention for tremor and gait disorders in PD patients will be compared.
• 1.Aged 50 years or older;
• 2.Confirmed diagnosis of idiopathic Parkinson's disease (IPD) according to the 2015 MDS diagnostic criteria, with tremor and gait disturbance;
• 3.Disease duration ≥2 years after diagnosis, stable condition, and ability to cooperate with study assessment and intervention;
• 4.Stable medication dosage for at least 4 weeks prior to the trial;
• 5.Good response to Levodopa therapy;
• 6.Capable of independent walking (without assistive devices) for at least 5 minutes and able to complete gait testing independently.
• 7.Signed informed consent form, with the participant or their legal guardian able to understand and willing to participate in this study.