Learn About Muenke Syndrome

What is the definition of Muenke Syndrome?

Muenke syndrome is a condition characterized by the premature closure of certain bones of the skull (craniosynostosis) during development, which affects the shape of the head and face.

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What are the causes of Muenke Syndrome?

A particular mutation in the FGFR3 gene causes Muenke syndrome. The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. The mutation associated with Muenke syndrome causes the FGFR3 protein to be overly active, which interferes with normal bone growth and allows the bones of the skull to fuse before they should.

How prevalent is Muenke Syndrome?

Muenke syndrome occurs in about 1 in 30,000 newborns. This condition accounts for an estimated 4 percent of all cases of craniosynostosis.

Is Muenke Syndrome an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

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Who are the sources who wrote this article ?

Published Date: March 01, 2019Published By: National Institutes of Health

What are the Latest Advances for Muenke Syndrome?
Management of ventriculomegaly in pediatric patients with syndromic craniosynostosis: a single center experience.
Summary: Management of ventriculomegaly in pediatric patients with syndromic craniosynostosis: a single center experience.
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