Multicentric Castleman Disease (MCD)
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Multicentric Castleman Disease (MCD) Overview

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Learn About Multicentric Castleman Disease (MCD)

View Main Condition: Castleman Disease

What is the definition of Multicentric Castleman Disease (MCD)?
Multicentric Castleman Disease (MCD) is a rare disease that affects the lymph nodes and related tissues. It is a form of Castleman disease that is "systemic" and involves multiple regions of lymph nodes (as opposed to unicentric Castleman disease, which involves a single lymph node or single region of lymph nodes). The signs and symptoms of MCD are often nonspecific, and are mild in some people but serious in others. Symptoms may include enlarged lymph nodes in multiple regions, fever, weight loss, nausea, rash, and/or an enlarged large liver and spleen. The disease is diagnosed based on the symptoms present, laboratory test results, imaging studies, and results of a biopsy of the lymph nodes which shows specific features when studied under the microscope. In some cases, MCD is caused by human herpesvirus-8 (HHV-8) and is referred to as HHV-8-associated MCD. In other cases, the cause is not known and it is referred to as HHV-8 negative MCD, or idiopathic MCD (iMCD).
What are the alternative names for Multicentric Castleman Disease (MCD)?
  • Multicentric Castleman Disease
  • Idiopathic multicentric Castleman's disease
  • MCD
  • Multicentric giant lymph node hyperplasia
  • Multicentric plasma cell variant of Castleman's disease
  • PMCD
  • Plasmablastic multicentric Castleman disease
Who are the top Multicentric Castleman Disease (MCD) Local Doctors?
Elite in Multicentric Castleman Disease (MCD)
Dr. Sudipto Mukherjee
Hematology | Oncology
Elite in Multicentric Castleman Disease (MCD)
Dr. Sudipto Mukherjee
Hematology | Oncology

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
866-223-8100
Languages Spoken:
English, Bengali, Hindi
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Sudipto Mukherjee is a Hematologist and an Oncologist practicing medicine in Cleveland, Ohio. Dr. Mukherjee is rated as an Elite provider by MediFind in the treatment of Multicentric Castleman Disease (MCD). He is also highly rated in 34 other conditions, according to our data. His clinical expertise encompasses Multicentric Castleman Disease (MCD), Castleman Disease, Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), and Bone Marrow Aspiration. Dr. Mukherjee is board certified in American Board Of Internal Medicine, 2019.

Elite in Multicentric Castleman Disease (MCD)
Eric Oksenhendler
Elite in Multicentric Castleman Disease (MCD)
Eric Oksenhendler
Paris, FR 

Eric Oksenhendler practices practicing medicine in Paris, France. Mr. Oksenhendler is rated as an Elite expert by MediFind in the treatment of Multicentric Castleman Disease (MCD). He is also highly rated in 16 other conditions, according to our data. His clinical expertise encompasses Castleman Disease, Multicentric Castleman Disease (MCD), Lymphoid Hyperplasia, Common Variable Immune Deficiency, and Splenectomy.

 
 
 
 
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Elite in Multicentric Castleman Disease (MCD)
Lionel Galicier
Elite in Multicentric Castleman Disease (MCD)
Lionel Galicier
Université Paris Est, 
Creteil, FR 

Lionel Galicier practices practicing medicine in Creteil, France. Mr. Galicier is rated as an Elite expert by MediFind in the treatment of Multicentric Castleman Disease (MCD). He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Castleman Disease, Multicentric Castleman Disease (MCD), Thrombocytopenia, Splenectomy, and Bone Marrow Aspiration.

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What are the latest Multicentric Castleman Disease (MCD) Clinical Trials?
A Phase II Study of Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease
A Phase II Study of Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease
Enrollment Status: Recruiting
Publish Date: March 18, 2026
Intervention Type: Drug
Study Phase: Phase 2

Background: Primary effusion lymphoma (PEL), plasmablastic lymphoma (PBL), and Multicentric Castleman Disease (MCD) are aggressive forms of cancer that affects cells in the immune system and lymph nodes. How they develop is not well understood, and these diseases do not respond well to standard treatments for other types of lymphomas.

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Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)
Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)
Enrollment Status: Recruiting
Publish Date: March 12, 2026
Intervention Type: Drug
Study Phase: Phase 2

Background: Kaposi sarcoma herpesvirus (KSHV)-associated inflammatory cytokine syndrome (KICS) and KSHV-multicentric Castleman disease (MCD) occur in people living with HIV. These diseases cause severe inflammation that can be fatal if not treated.

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are some Advocacy Organizations?
castleman-disease

The Castleman Disease Collaborative Network (CDCN) is a global initiative dedicated to accelerating research and treatment for Castleman disease and revolutionizing biomedical research.