Multicentric Castleman Disease (MCD) Overview

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Learn About Multicentric Castleman Disease (MCD)

View Main Condition: Castleman Disease

What is the definition of Multicentric Castleman Disease (MCD)?
Multicentric Castleman Disease (MCD) is a rare disease that affects the lymph nodes and related tissues. It is a form of Castleman disease that is "systemic" and involves multiple regions of lymph nodes (as opposed to unicentric Castleman disease, which involves a single lymph node or single region of lymph nodes). The signs and symptoms of MCD are often nonspecific, and are mild in some people but serious in others. Symptoms may include enlarged lymph nodes in multiple regions, fever, weight loss, nausea, rash, and/or an enlarged large liver and spleen. The disease is diagnosed based on the symptoms present, laboratory test results, imaging studies, and results of a biopsy of the lymph nodes which shows specific features when studied under the microscope. In some cases, MCD is caused by human herpesvirus-8 (HHV-8) and is referred to as HHV-8-associated MCD. In other cases, the cause is not known and it is referred to as HHV-8 negative MCD, or idiopathic MCD (iMCD).
What are the alternative names for Multicentric Castleman Disease (MCD)?
  • Multicentric Castleman Disease
  • Idiopathic multicentric Castleman's disease
  • MCD
  • Multicentric giant lymph node hyperplasia
  • Multicentric plasma cell variant of Castleman's disease
  • PMCD
  • Plasmablastic multicentric Castleman disease
Who are the top Multicentric Castleman Disease (MCD) Local Doctors?
Sudipto Mukherjee
Elite in Multicentric Castleman Disease (MCD)
Dr. Sudipto Mukherjee
Hematology | Oncology
Elite in Multicentric Castleman Disease (MCD)
Dr. Sudipto Mukherjee
Hematology | Oncology

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
866-223-8100
Languages Spoken:
English, Bengali, Hindi
See accepted insurances
Offers Telehealth

Sudipto Mukherjee is a Hematologist and an Oncologist in Cleveland, Ohio. Dr. Mukherjee is rated as an Elite provider by MediFind in the treatment of Multicentric Castleman Disease (MCD). His top areas of expertise are Multicentric Castleman Disease (MCD), Castleman Disease, Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), and Bone Marrow Aspiration.

Carlos M. De Castro Iii
Advanced in Multicentric Castleman Disease (MCD)
Dr. Carlos M. De Castro Iii
Hematology Oncology | Hematology
Advanced in Multicentric Castleman Disease (MCD)
Dr. Carlos M. De Castro Iii
Hematology Oncology | Hematology

Duke Blood Cancer Center

2400 Pratt St, 
Durham, NC 
919-684-8964
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Carlos De Castro Iii is a Hematologist Oncology specialist and a Hematologist in Durham, North Carolina. Dr. De Castro Iii is rated as an Advanced provider by MediFind in the treatment of Multicentric Castleman Disease (MCD). His top areas of expertise are Paroxysmal Nocturnal Hemoglobinuria (PNH), Aplastic Anemia, Acute Myeloblastic Leukemia without Maturation, Acute Myeloid Leukemia (AML), and Bone Marrow Aspiration. Dr. De Castro Iii is currently accepting new patients.

 
 
 
 
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Taewoong Choi
Advanced in Multicentric Castleman Disease (MCD)
Dr. Taewoong Choi
Hematology Oncology | Hematology | Transplant Surgery
Advanced in Multicentric Castleman Disease (MCD)
Dr. Taewoong Choi
Hematology Oncology | Hematology | Transplant Surgery

Duke Blood Cancer Center

2400 Pratt St, 
Durham, NC 
919-684-8964
Languages Spoken:
English, Korean
See accepted insurances
Accepting New Patients
Offers Telehealth

Taewoong Choi is a Hematologist Oncology specialist and a Hematologist in Durham, North Carolina. Dr. Choi is rated as an Advanced provider by MediFind in the treatment of Multicentric Castleman Disease (MCD). His top areas of expertise are Multiple Myeloma, Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance (MGUS), Bone Marrow Transplant, and Bone Marrow Aspiration. Dr. Choi is currently accepting new patients.

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What are the latest Multicentric Castleman Disease (MCD) Clinical Trials?
A Phase II, Single-Arm Open-Label Multi-Center Study of Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease
A Phase II, Single-Arm Open-Label Multi-Center Study of Ruxolitinib in Previously Treated Idiopathic Multicentric Castleman Disease
Enrollment Status: Recruiting
Publish Date: November 06, 2025
Intervention Type: Drug
Study Phase: Phase 2

Summary: The research study is being done to look at the effects of ruxolitinib in adults with idiopathic Multicentric Castleman Disease (iMCD) that has not gotten better from taking siltuximab or tocilizumab, or who cannot take those medications.

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Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)
Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)
Enrollment Status: Recruiting
Publish Date: September 15, 2025
Intervention Type: Drug
Study Phase: Phase 2

Background: Kaposi sarcoma herpesvirus (KSHV)-associated inflammatory cytokine syndrome (KICS) and KSHV-multicentric Castleman disease (MCD) occur in people living with HIV. These diseases cause severe inflammation that can be fatal if not treated.

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are some Advocacy Organizations?
castleman-disease

The Castleman Disease Collaborative Network (CDCN) is a global initiative dedicated to accelerating research and treatment for Castleman disease and revolutionizing biomedical research.