Learn About Multiple Endocrine Neoplasia
Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.
Mutations in the MEN1, RET, and CDKN1B genes can cause multiple endocrine neoplasia.
Multiple endocrine neoplasia type 1 affects about 1 in 30,000 people; multiple endocrine neoplasia type 2 affects an estimated 1 in 35,000 people. Among the subtypes of type 2, type 2A is the most common form, followed by FMTC. Type 2B is relatively uncommon, accounting for about 5 percent of all cases of type 2. The prevalence of multiple endocrine neoplasia type 4 is unknown, although the condition appears to be rare.
Multiple endocrine neoplasia type 1 usually has an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the MEN1 gene in each cell. In most cases, the altered gene is inherited from an affected parent. The remaining cases are a result of new mutations in the MEN1 gene and occur in people with no history of the disorder in their family.
Kate Lines practices in Oxford, United Kingdom. Ms. Lines is rated as an Elite expert by MediFind in the treatment of Multiple Endocrine Neoplasia. Her top areas of expertise are Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia, Pancreatic Islet Cell Tumor, Autosomal Dominant Hypocalcemia, and Parathyroidectomy.
Maria Brandi practices in Florence, Italy. Brandi is rated as an Elite expert by MediFind in the treatment of Multiple Endocrine Neoplasia. Their top areas of expertise are Osteoporosis, Hypophosphatemia, X-Linked Hypophosphatemia, Parathyroidectomy, and Hormone Replacement Therapy (HRT).
Erasmus MC
Wouter De Herder practices in Rotterdam, Netherlands. De Herder is rated as an Elite expert by MediFind in the treatment of Multiple Endocrine Neoplasia. Their top areas of expertise are Neuroendocrine Tumor, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia, Pancreaticoduodenectomy, and Oophorectomy.
Summary: The aim of this research is to analyze whether nutritional intervention combined with a multicomponent physical training program based on strength, balance, and aerobic exercises can prevent disability caused during hospitalization in individuals aged 75 years or older admitted for medical conditions, thereby improving functional and cognitive capacity. To achieve this objective, we will conduct a...
Background: \- Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. These problems include adrenal gland tumors, hormone changes, and problems with the bones and other organs. Not much is k...
Published Date: March 01, 2017
Published By: National Institutes of Health