Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Observational
SUMMARY

This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hematologic malignancies). This may help researchers learn more about the effects of whole brain radiation therapy on memory and thinking in patients with blood cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 years or older

• Treatment with radiation therapy to the brain for a hematologic malignancy (ex. primary central nervous system lymphoma \[PCNSL\], secondary central nervous system lymphoma \[SCNSL\], leukemia, myeloma)

• Proficient and capable of completing tests in English

• Patients with claustrophobia are eligible if the claustrophobia is managed with medication

• Patients with cognitively-impairment are eligible if the impairment is managed with medication

• Patients who are pregnant

Locations
United States
Texas
M D Anderson Cancer Center
RECRUITING
Houston
Contact Information
Primary
Dustin M Silk
dmdmsilk@mdanderson.orgsilk@mdanderson.org
713-563-3090
Time Frame
Start Date: 2020-01-09
Estimated Completion Date: 2026-10-31
Participants
Target number of participants: 100
Treatments
Observational (neurocognitive assessment, questionnaires, MRI)
Patients undergo neurocognitive function assessments, complete questionnaires over 8-10 minutes and undergo standard of care MRI at baseline (within 4 weeks before the first day of WBRT), 2, 6, 12 months after RT completion, then annually for 5 years.
Related Therapeutic Areas
Sponsors
Leads: M.D. Anderson Cancer Center

This content was sourced from clinicaltrials.gov