Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis.

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental insights into disease pathobiology - which may thereby lead to effective strategies for halting its progression in its earliest stages.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 10
Maximum Age: 20
Healthy Volunteers: t
View:

• Ability to provide informed consent (or assent for minors)

• Relapsing-remitting MS diagnosis per 2017 McDonald criteria

• Ages ≥ 10 years to ≤ 20 years

• Diagnosis of MS or first clinical symptom of MS (whichever comes first) within ≤ 36 months from the time of enrollment.

• Ability to provide informed consent (or assent for minors)

• Age-, sex-, \& BMI-matched to pediatric MS subjects (1:1 allocation)

• Healthy children and young adults from the local communities

Locations
United States
Pennsylvania
Children's Hospital of Philadelphia
RECRUITING
Philadelphia
Virginia
University of Virginia
RECRUITING
Charlottesville
Contact Information
Primary
J Nicholas Brenton, MD
jnb8h@virginia.edu
434-982-3936
Backup
Margaret Keller
mfk8e@hscmail.mcc.virginia.edu
434-297-4102
Time Frame
Start Date: 2021-06-03
Estimated Completion Date: 2025-06-01
Participants
Target number of participants: 116
Treatments
Pediatric MS Subjects
Subjects with pediatric MS will undergo fasting lab work, non-contrasted MRI, DEXA scan, and surveys.
Healthy controls
Non-MS pediatric control subjects who will undergo fasting lab work, DEXA scan, and surveys for comparison to control group.
Sponsors
Leads: University of Virginia
Collaborators: Children's Hospital of Philadelphia

This content was sourced from clinicaltrials.gov