Identification of New Biomarkers Useful to Define the Course of Multiple Sclerosis and Study of the Mechanisms That Promote Synaptic Damage
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit. Subjects with other chronic neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD), and healthy subjects subjected to blood sampling and / or lumbar puncture for clinical reasons will be recruited As control groups.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Male and female patients (age between 18 and 65 years)
• Diagnosis of MS in accordance with McDonald's (2010 rev) criteria,
• EDSS between 0 and 5.5 (included),
• Patients able to provide informed consent to participation in the study
Locations
Other Locations
Italy
IRCCS Neuromed
RECRUITING
Pozzilli
Contact Information
Primary
Diego Centonze, MD
centonze@uniroma2.it
+39 3934444159
Backup
Mario Stampanoni Bassi, MD
mario_sb@hotmail.it
+39 3460181370
Time Frame
Start Date: 2017-11-22
Estimated Completion Date: 2027-09-30
Participants
Target number of participants: 300
Treatments
multiple sclerosis patients
lumbar puncture, microRNAs quantification in blood and CSF samples, SNPs analysis
neurodegenerative disease patients
lumbar puncture, microRNAs quantification in blood and CSF samples, SNPs analysis
control subjects
lumbar puncture, microRNAs quantification in blood and CSF samples, SNPs analysis
Related Therapeutic Areas
Sponsors
Collaborators: IRCCS Multimedica
Leads: Neuromed IRCCS