Learn About Multisystem Inflammatory Syndrome in Children (MIS-C)

What is the definition of Multisystem Inflammatory Syndrome in Children (MIS-C)?
Multisystem inflammatory syndrome in children (MIS-C) is a rare syndrome that appears to be linked to COVID-19 infection, in which different body organs become severely inflamed, such as the skin, eyes, brain, gastrointestinal system, heart, lungs, and kidneys.
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What are the symptoms of Multisystem Inflammatory Syndrome in Children (MIS-C)?
Symptoms of multisystem inflammatory syndrome in children can vary and require emergency treatment to prevent permanent organ damage. Symptoms may include fatigue, fever of 100.4° lasting 24 hours or longer, bloodshot eyes (conjunctivitis), rash, red, cracked lips, vomiting, diarrhea, severe abdominal pain, neck pain, difficulty breathing (dyspnea) or rapid breathing, cough, sore throat, chest pain or pressure, dizziness, confusion, loss of consciousness, bluish lips or face, low blood pressure, heart inflammation (myocarditis), rapid heartbeat, redness or swelling of lips, tongue (with red bumps), hands, or feet, and enlarged lymph nodes.
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What are the current treatments for Multisystem Inflammatory Syndrome in Children (MIS-C)?
While treatment for children with multisystem inflammatory syndrome depends on the organs that are affected and the severity of the symptoms, children with this syndrome will usually need to be treated in the hospital by a multidisciplinary team with both supportive care (blood pressure medications, fluids, and oxygen to alleviate symptoms) and drugs to treat inflammation, such as antibiotics, steroid therapy, intravenous immunoglobulin (IVIG), and cytokine targeted therapies. Some children with this syndrome may need to be treated in the pediatric intensive care unit with ventilators, anticoagulants, and, in rare cases, extracorporeal membrane oxygenation.
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What are the latest Multisystem Inflammatory Syndrome in Children (MIS-C) Clinical Trials?
Cellular and Molecular Characterization of the Immune Response in Children and Adolescents With Inflammatory Syndrome in Children (MIS-C)

Summary: Multi-system inflammatory syndrome in children (MIS-C) is a post-viral inflammatory vasculopathy of children and adolescents following Covid-19 infection. It affects one of 1000-5000 children. Latency between mild or asymptomatic Covid-19 infection and MIS-C is 4-6 weeks. The immune response in MIS-C seems to be dysregulated and different from that during acute SARS-CoV-2 infection. The investigat...

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Immunological Mechanisms in Multisystem Inflammatory Syndrome in Children

Summary: This study seeks to explore immunological mechanisms in patients with Multisystem Inflammatory Syndrome in Children (MIS-C) to improve the understanding of this pathogenesis of this disease. In a cohort of MIS-C patients diagnosed during the Wild type, Alpha, Delta and Omicron waves, research samples will be analyzed for whole-blood RNA expression, proteomics, inflammatory cytokines, cellular immu...

What are the Latest Advances for Multisystem Inflammatory Syndrome in Children (MIS-C)?
Can charcoal hemoperfusion treatment be an option for pediatric MIS-C patients? A single-center experience in a tertiary pediatric intensive care unit.
Neonatal MIS-C: Managing the Cytokine Storm.
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Cyclosporine for the treatment of multisystem inflammatory syndrome in children with coronary artery aneurysms.