Multisystem Inflammatory Syndrome in Children (MIS-C)
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Multisystem Inflammatory Syndrome in Children (MIS-C) Overview

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Learn About Multisystem Inflammatory Syndrome in Children (MIS-C)

What is the definition of Multisystem Inflammatory Syndrome in Children (MIS-C)?
Multisystem inflammatory syndrome in children (MIS-C) is a rare syndrome that appears to be linked to COVID-19 infection, in which different body organs become severely inflamed, such as the skin, eyes, brain, gastrointestinal system, heart, lungs, and kidneys.
What are the symptoms of Multisystem Inflammatory Syndrome in Children (MIS-C)?
Symptoms of multisystem inflammatory syndrome in children can vary and require emergency treatment to prevent permanent organ damage. Symptoms may include fatigue, fever of 100.4° lasting 24 hours or longer, bloodshot eyes (conjunctivitis), rash, red, cracked lips, vomiting, diarrhea, severe abdominal pain, neck pain, difficulty breathing (dyspnea) or rapid breathing, cough, sore throat, chest pain or pressure, dizziness, confusion, loss of consciousness, bluish lips or face, low blood pressure, heart inflammation (myocarditis), rapid heartbeat, redness or swelling of lips, tongue (with red bumps), hands, or feet, and enlarged lymph nodes.
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What are the current treatments for Multisystem Inflammatory Syndrome in Children (MIS-C)?
While treatment for children with multisystem inflammatory syndrome depends on the organs that are affected and the severity of the symptoms, children with this syndrome will usually need to be treated in the hospital by a multidisciplinary team with both supportive care (blood pressure medications, fluids, and oxygen to alleviate symptoms) and drugs to treat inflammation, such as antibiotics, steroid therapy, intravenous immunoglobulin (IVIG), and cytokine targeted therapies. Some children with this syndrome may need to be treated in the pediatric intensive care unit with ventilators, anticoagulants, and, in rare cases, extracorporeal membrane oxygenation.
Who are the top Multisystem Inflammatory Syndrome in Children (MIS-C) Local Doctors?
Elite in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Edward M. Behrens
Pediatric Rheumatology
Elite in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Edward M. Behrens
Pediatric Rheumatology
Referral may be required
Before you request

Office

3401 Civic Center Blvd, 
Philadelphia, PA 
215-590-1000
Languages Spoken:
English
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Accepting New Patients

Edward Behrens is a Pediatric Rheumatologist practicing medicine in Philadelphia, Pennsylvania. Dr. Behrens is rated as an Elite provider by MediFind in the treatment of Multisystem Inflammatory Syndrome in Children (MIS-C). He is also highly rated in 3 other conditions, according to our data. His clinical expertise encompasses Multisystem Inflammatory Syndrome in Children (MIS-C), Juvenile Idiopathic Arthritis (JIA), Liver Failure, and Arthritis. Dr. Behrens is currently accepting new patients.

Elite in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Lauren A. Henderson
Pediatric Rheumatology
Elite in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Lauren A. Henderson
Pediatric Rheumatology
Referral may be required
Before you request

Pediatric Rheumatology Program

300 Longwood Ave, 
Boston, MA 
617-355-6117
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Lauren Henderson is a Pediatric Rheumatologist practicing medicine in Boston, Massachusetts. Dr. Henderson is rated as an Elite provider by MediFind in the treatment of Multisystem Inflammatory Syndrome in Children (MIS-C). She is also highly rated in 5 other conditions, according to our data. Her clinical expertise encompasses Juvenile Idiopathic Arthritis (JIA), Multisystem Inflammatory Syndrome in Children (MIS-C), Arthritis, and Kawasaki Disease. Dr. Henderson is currently accepting new patients.

 
 
 
 
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Distinguished in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Robert J. Pearlstein
Geriatrics | Internal Medicine
Distinguished in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dr. Robert J. Pearlstein
Geriatrics | Internal Medicine
Referral may be required
Before you request

Suburban Geriatrics Inc

2901 Jolly Road, 
Plymouth Meeting, PA 
610-272-8221
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Robert Pearlstein is a primary care provider, practicing in Geriatrics and Internal Medicine in Plymouth Meeting, Pennsylvania. Dr. Pearlstein is rated as a Distinguished provider by MediFind in the treatment of Multisystem Inflammatory Syndrome in Children (MIS-C). He is also highly rated in 180 other conditions, according to our data. His clinical expertise encompasses Dementia, Alzheimer's Disease, Painful Swallowing, Gastrostomy, and Endoscopy. Dr. Pearlstein is board certified in  . Dr. Pearlstein is currently accepting new patients.

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What are the latest Multisystem Inflammatory Syndrome in Children (MIS-C) Clinical Trials?
Cardiovascular Evaluation 5 Years After Multisystem Inflammatory Syndrome in Children (MIS-C)
Cardiovascular Evaluation 5 Years After Multisystem Inflammatory Syndrome in Children (MIS-C)
Enrollment Status: Recruiting
Publish Date: June 22, 2026

Summary: Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection that frequently affects the cardiovascular system. Although acute cardiac abnormalities usually resolve, the long-term cardiovascular consequences of MIS-C remain uncertain. Previous follow-up of this cohort 2 years after MIS-C identified signs of subclinical cardiovascular abnormali...

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