MEND Repair & Recover Clinical Trial
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the ability of EAA-based to increase skeletal muscle metabolic activity, reduce inflammation, and induce muscle fiber hypertrophy, as well as preserve skeletal muscle mass and physical performance up to 6 months after injury. Participants will be randomized in a 1:1 ratio to 1) standard of care (no dietary intervention) or 2) EAA-based supplementation.
• Hospital inpatient
• Age ≥ 65 years old on admission
• Low-energy mechanism of injury
• Diagnosis of femur fracture (OTA 31, 32, or 33 fracture)
• Indicated for surgical fixation
• Able to provide informed consent