SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly

Who is this study for? Older adult patients with Urothelial Bladder Carcinoma and can speak French
What treatments are being studied? Sarcopenia+Mobility Measurement
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy. According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry). This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study. The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter. Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication. Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• confirmed urothelial bladder carcinoma ( RTUV)

‣ indication of radical cystectomy

⁃ Able, informed and with informed consent for the study

⁃ affiliated to the social security system

⁃ talking French

Locations
Other Locations
France
Caen University Hospital
RECRUITING
Caen
APHM
RECRUITING
Marseille
Rouen UH
SUSPENDED
Rouen
Contact Information
Primary
françois fournel
fournel-f@chu-caen.fr
+33231065488
Backup
helene legros
legros-h@chu-caen.fr
Time Frame
Start Date: 2017-10-30
Estimated Completion Date: 2026-02-01
Participants
Target number of participants: 69
Treatments
Other: Sarcopenic
sarcopenic status the day before cystectomy.
Other: not sarcopenic
sarcopenic status the day before cystectomy.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Caen

This content was sourced from clinicaltrials.gov