Comparison of Serum Myokine Dosages and Imaging Methods in the Evaluation of Sarcopenia in Patients With Hepatocellular Carcinoma

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

It is known that some substances present in the blood, called 'myokines,' influence muscle loss. Some may accelerate this loss, while others may prevent it. Inflammatory substances in the blood can also contribute to muscle loss. Sarcopenia is assessed by an imaging technique called 'Skeletal Muscle Mass Index (SMI)' to measure muscle mass. This analysis can be done from radiological examinations. Sarcopenia has a serious impact on patients with hepatocellular carcinoma. It increases the risk of death, cancer recurrence, and decreases the response to treatments. Therefore, the investigators want to determine if blood tests for myokines obtained by simple blood draw can improve the assessment of sarcopenia in this specific setting.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• New diagnosis of HCC made by radiology and/or histopathology according to EASL criteria, regardless of the degree of hepatic fibrosis (METAVIR F0-F4)

• Availability of a pre-therapeutic three-phase contrast-enhanced abdominal-pelvic CT scan.

Locations
Other Locations
France
Damien JOLLY
RECRUITING
Reims
Contact Information
Primary
Elia GIGANTE
egigante@chu-reims.fr
03 26 78 33 43
Time Frame
Start Date: 2024-11-22
Estimated Completion Date: 2026-05-22
Participants
Target number of participants: 139
Treatments
Experimental: Patients with hepatocellular carcinoma
Related Therapeutic Areas
Sponsors
Leads: CHU de Reims

This content was sourced from clinicaltrials.gov