MUSCLE EFFECTS OF NEUROMUSCULAR ELECTROSTIMULATION IN MECHANICALLY VENTILATED PATIENTS IN AN ICU

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

To prevent the development of ICUAW, both early mobilization and neuromuscular electrical stimulation (NMES) have been shown to prevent muscle atrophy in critically ill patients by preserving muscle mass. Furthermore, it is of great value that muscle assessment using kinesiological ultrasound becomes routine to monitor this patient's profile with regard to strength, muscle quality and muscle mass. Our objective is to evaluate the muscular changes promoted by NMES in patients under mechanical ventilation. This is a randomized clinical trial study, which will perform NMES sessions for at least 10 days in mechanically ventilated patients. They will also undergo ultrasound assessments of the quadriceps. Patients will be divided into a control group and an NMES group. In addition, general information recorded in the medical record will be collected, such as basic characteristics, laboratory tests and general assessments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥18 years;

• On mechanical ventilation in the first 24 hours;

• Provision of written, informed and/or agreed consent for a family member.

Locations
Other Locations
Brazil
Pedro Ernesto University Hospital
RECRUITING
Rio De Janeiro
State University of Rio de Janeiro
RECRUITING
Rio De Janeiro
Universidade do Estado do Rio de Janeiro
RECRUITING
Rio De Janeiro
Contact Information
Primary
Larissa A Lago
larissaalago@gmail.com
21983255721
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2026-04-01
Participants
Target number of participants: 22
Treatments
Experimental: neuromuscular electrical stimulation (NMES)
For the NMES group, NMES therapy will be performed for 1 hour, once a day and for 10 days. Using the following parameters: Biphasic and symmetrical rectangular pulse, with a frequency of 50Hz, pulse width of 500μs, ON time of 10 seconds, OFF time of 15 seconds, 3 seconds of rise time and 2 seconds of descent time. The intensity is increased to the point that there is complete muscle contraction, visible or palpable. The maximum intensity will be 120 mA.
Active_comparator: Placebo
This group will perform conventional physiotherapy according to institutional protocol. Rehabilitation was oriented towards achieving daily motor milestones (sitting on the edge of the bed, sitting in an armchair, getting up and walking) according to the CPAx scale. The same electrostimulation device will be installed, but it will not be turned on.
Related Therapeutic Areas
Sponsors
Leads: Universidade Federal do Rio de Janeiro
Collaborators: Hospital Universitario Pedro Ernesto

This content was sourced from clinicaltrials.gov