A ICOPE Intense Program Combined With Ketone Ester Pilot Study
ICOPE could constitute the reference model of care for healthy aging. More specifically, our hypothesis is that the intervention implemented in ICOPE may directly or indirectly prevent immuno-senescence, the loss of mobility and the cognitive decline. In future Geroscience clinical trials, ICOPE-Intense could become a benchmark to reduce the rate of aging with a strong non-pharmacological intervention and state a reference intervention to compare with new gerotherapeutic drugs.
• Independent-living (ADL ≥5/6)
• Men and women
• Mobility impairment (5 Chair-rise test \>12 seconds)
• Sedentarism (spend six or more hours per day sitting or lying down)
• Positive screening for cognitive impairment according to the ICOPE screening tool with MMSE \[25-28\]
• BMI ≥25 kg/m2