Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 80
Healthy Volunteers: f
View:
• Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation
• Planned use of rocuronium for neuromuscular blockade
• Quantitative neuromuscular monitoring planned during anesthesia
• American Society of Anesthesiologists physical status I-III
• Ability to provide written informed consent
• Completion of preoperative frailty and sarcopenia assessment
Locations
Other Locations
Turkey
Betul Kozanhan
RECRUITING
Konya
Contact Information
Primary
Betül kozanhan, M.D.
betulkozanhan@gmail.com
05055044808
Time Frame
Start Date: 2026-05-13
Estimated Completion Date: 2026-08-05
Participants
Target number of participants: 100
Treatments
Group/Cohort 1-Frailty
Presence of frailty based on the Fried frailty phenotype.
Group/Cohort 2-Sarcopenia
Presence of sarcopenia based on preoperative clinical and ultrasonographic assessment.
Group/Cohort 3 - Frail and Sarcopenic Group
Geriatric patients who meet the criteria for both frailty and sarcopenia.
Group/Cohort 4 - Control Group
Geriatric patients who meet neither frailty nor sarcopenia criteria.
Related Therapeutic Areas
Sponsors
Leads: Konya Meram State Hospital