Clinical Characteristics, Prognosis and Biomarkers of Myasthenia Gravis: a Prospective Cohort Study in China

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Observational
SUMMARY

The goal of this prospective cohort study is to investigate long-term therapeutic strategies for myasthenia gravis (MG) and identify potential biomarkers. The main questions it aims to answer are: 1. Whether low-dose oral steroids may lead to a reduction in the recurrence rate among patients with MG. 2. To identify potential biomarkers that can predict disease progression and prognosis. This study recruits well-controlled patients with MG. Based on patient preferences and considerations such as coexisting conditions (e.g., uncontrolled hypertension, diabetes, severe osteoporosis, obesity), the participants will be non-randomly divided into two groups: a maintenance steroid therapy group and a withdrawal group (withdraw all immunosuppresants). Subsequently, these groups of patients will undergo long-term follow-up assessments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• 1: Attended the outpatient department of neurology of PUMCH from 9/30/2022 to 9/30/2024.

• 2: Diagnosed as myasthenia gravis.

• 3: Follow-up time at PUMCH\>6 months.

• 4: The patient understood and signed the informed consent form.

Locations
Other Locations
China
Peking Union Medical College Hospital
RECRUITING
Beijing
Contact Information
Primary
Yuzhou Guan
guanyz001@163.com
8610-69155817
Time Frame
Start Date: 2023-08-20
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 202
Treatments
maintenance steroid therapy group
Maintaining low-dose oral steroids
immunosuppresants withdrawal group
Withdraw all immunosuppresants
Sponsors
Leads: Peking Union Medical College Hospital

This content was sourced from clinicaltrials.gov