Non-Steroidal Anti-Inflammatory Drugs Versus Conventional Treatment in Acute Myocarditis (INFLAMA Trial)
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of a 3-week ibuprofen tapering regimen compared to conventional analgesic treatment (acetaminophen) in patients with acute myocarditis and left ventricular ejection fraction ≥50%. The objective is to assess the reduction in late gadolinium enhancement on cardiac magnetic resonance imaging at 6-month follow-up.
• Aged 18 years or older.
• Patients hospitalized for confirmed acute myocarditis and left ventricular ejection fraction ventricular \>50%.
• Elevated troponin I/T (3 times above the upper limit of normal).
• Absence of acute heart failure.
• Absence of ischemic heart disease (ruled out by coronary angiography or coronary CT in individuals over 40 years).
• Diagnostic criteria for myocarditis (Lake Louise, 2018 update) by cardiac magnetic resonance imaging.