Learn About Myoclonic Epilepsy

What is the definition of Myoclonic Epilepsy?
Myoclonic epilepsy is a type of seizure disorder characterized by quick jerking movements due to uncontrolled muscle contractions caused by abnormal electrical impulses in the brain. Unlike grand mal (tonic-clonic) seizures, during a myoclonic seizure the affected individual does not lose consciousness. There are several types of myoclonic epilepsy, including infantile spasms, Lennox-Gastaut Syndrome, juvenile myoclonic epilepsy, and progressive myoclonic epilepsy, among others.
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What are the symptoms of Myoclonic Epilepsy?
Symptoms of myoclonic epilepsy depend on the type and usually affects the neck, shoulders, and upper arms. Symptoms of myoclonic epilepsy may include quick, uncontrolled muscle jerks; rhythmic movements; arms flinging outward; knees pulling up; body stiffening; and unusual clumsiness. Myoclonic seizures may occur with atonic seizures, which cause limp muscles. When myoclonic epilepsy worsens, it is known as progressive myoclonic epilepsy, which is a rare seizure disorder characterized by both myoclonic and tonic-clonic (grand mal) seizures.
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What are the current treatments for Myoclonic Epilepsy?
Treatment for myoclonic epilepsy depends on the type, frequency, and severity of the seizures and may include anti-seizure (anti-epileptic) medications, ketogenic diet, vagus nerve stimulator (VNS) implantation, and surgery.
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What are the latest Myoclonic Epilepsy Clinical Trials?
Development of a Practical, Minimally Invasive Seizure Gauge
Summary: The researchers are trying to assess changes in physiological signals before and during seizures.
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety, and Tolerability of Soticlestat as Adjunctive Therapy in Pediatric and Young Adult Subjects With Dravet Syndrome (DS)
Summary: The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of convulsive seizures in children and young adults with DS.~Participants will receive their standard antiseizure therapy, plus either a tablet of soticlestat or placebo for 16 weeks. A placebo looks just like soticlestat but will not have any medicine in it.~Participants may continue treatmen...
What are the Latest Advances for Myoclonic Epilepsy?
Stiripentol add-on therapy for drug-resistant focal epilepsy.
Summary: Stiripentol add-on therapy for drug-resistant focal epilepsy.
Therapeutic approach to neurological manifestations of Angelman syndrome.
Summary: Therapeutic approach to neurological manifestations of Angelman syndrome.
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Perampanel as adjuvant treatment in epileptic encephalopathies: A multicenter study in routine clinical practice.
Summary: Perampanel as adjuvant treatment in epileptic encephalopathies: A multicenter study in routine clinical practice.