Two Cycles VS Three Cycles Induction Chemotherapy Plus Concurrent Chemoradiotherapy in T1-4N2-3 Locally Advanced Nasopharyngeal Carcinoma
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether 2 cycles induction chemotherapy combined with concurrent chemoradiotherapy is not inferior to 3 cycles induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Age 18-65 years old;
• Pathologically confirmed non-keratinizing nasopharyngeal carcinoma;
• Stage T3-4N0-1 (according to the UICC/AJCC 8th);
• No distant metastasis;
• Have not received anti-cancer treatment in the past;
• ECOG (Eastern Cooperative Oncology Group of the United States): 0-1;
• Adequate hematologic, hepatic and renal function.
Locations
Other Locations
China
First Affiliated Hospital, Sun Yat-Sen University
RECRUITING
Guangzhou
Contact Information
Primary
Cheng-Tao Wang
wangcht5@mail.sysu.edu.cn
+862087755766
Time Frame
Start Date: 2023-05
Estimated Completion Date: 2030-05
Participants
Target number of participants: 474
Treatments
Experimental: 2 cycles
2 cycles induction + concurrent chemoradiotherapy
Active_comparator: 3 cycles
3 cycles induction + concurrent chemoradiotherapy
Related Therapeutic Areas
Sponsors
Leads: First Affiliated Hospital, Sun Yat-Sen University