What is the definition of Necrosis?

Necrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation, or chemicals. Necrosis cannot be reversed.

When large areas of tissue die due to a lack of blood supply, the condition is called gangrene.

Meningococcemia on the calves
Meningococcemia on the leg
Meningococcemia associated purpura
Necrosis of the toes


Kumar V, Abbas AK, Aster JC. Cellular responses to stress and toxic insults: adaptation, injury, and death. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 2.

  • Condition: Brain Metastases
  • Journal: Neurocirugia (English Edition)
  • Treatment Used: Stereotactic Radiosurgery
  • Number of Patients: 170
  • Published —
The study researched the incidence of radiation necrosis in patients with brain metastases receiving stereotactic radiosurgery.
  • Condition: Femoral Head Avascular Necrosis with HIV
  • Journal: Acta bio-medica : Atenei Parmensis
  • Treatment Used: Total Hip Arthroplasty
  • Number of Patients: 24
  • Published —
This study tested the safety and efficacy of using total hip arthroplasty to treat patients with femoral head avascular necrosis and HIV.
Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Behavioral
  • Participants: 112
  • Start Date: October 15, 2020
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