Imaging Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis (IRRAS-BM)
This trial uses multi-parametric magnetic resonance imaging (MRI) to develop and validate imaging risk score to predict radiation necrosis in participants with brain metastasis treated with radiation therapy. Diagnostic procedures, such as multi-parametric magnetic resonance imaging (MRI), may improve the ability to diagnose radiation necrosis early and help establish treatment strategies.
• Patients who underwent stereotactic radiosurgery (SRS, gamma-knife radiosurgery or cyberknife radiosurgery) for brain metastases
• Patients with lesions eligible for SRS :
‣ One to ten newly diagnosed brain metastases
⁃ Patients without acute neurological symptom
• Patients with a Karnofsky performance status score of 70 or higher
• Patients who underwent brain MRI within 1 month of enrollment
• Patients with measurable enhancing lesions on MRI.
• Patients who have available reference standard (second-look surgery for recurrence) or available follow up imaging for clinic-radiologic reference standard.
• A longest diameter \> 1.5 cm for tumor habitat analysis.