Evaluation of Regenerative Endodontic Treatment for Immature Teeth Using Two Different Forms of Demineralized Dentin Matrix and RetroMTA: Randomized Controlled Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment using RetroMTA in patients aged 9 to 15 years. The main questions it aims to answer are: Does the use of DDM improve clinical and radiographic outcomes such as root length, dentinal wall thickness, and apex closure? Is DDM a viable bioactive alternative to RetroMTA as a coronal sealing material in regenerative endodontic procedures? Researchers will compare three groups: one using RetroMTA, one using a DDM-TheraCal LC mixture, and one using TDM-Hydrogel, to see if these materials differ in their effects on regenerative outcomes. Participants will: Undergo two treatment visits including canal disinfection, induction of bleeding to form a blood clot scaffold, Receive placement of one of the study materials over the blood clot as a coronal barrier, Have clinical examinations and CBCT imaging at baseline and multiple follow-ups up to 12 months to assess treatment success through signs, symptoms, and radiographic changes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 9
Maximum Age: 15
Healthy Volunteers: t
View:

• Systemically healthy patients (i.e., free of any systemic diseases).

• Patients presenting with immature permanent single-rooted teeth.

• Age: 9 -15 years.

• Teeth diagnosed as either vital (asymptomatic irreversible pulpitis or symptomatic irreversible pulpitis and the bleeding didn't stop after 5 minutes application of hemostatic agent) or non-vital pulp.

Locations
Other Locations
Egypt
KafrelsheikhU
RECRUITING
Kafr Ash Shaykh
Contact Information
Primary
Dina Sarhan, Masters
dr.dinaabdullah954@gmail.com
01226083903
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2026-12
Participants
Target number of participants: 36
Treatments
Active_comparator: treated hyman dentin matrix hydrogel
material used for regenerative dentistry
Active_comparator: Theracal LC- Demineralized dentina matrix combination
material used for regenerative dentistry
Active_comparator: RetroMTA
material used for regenerative dentistry
Related Therapeutic Areas
Sponsors
Leads: Kafrelsheikh University

This content was sourced from clinicaltrials.gov