Necrosis Clinical Trials

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Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and/or severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications. The study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: t
View:

• Patients with necrotic pulps.

• Adult, healthy patients, older than 18 years old

• Males and females.

• Patient with the ability to understand and use pain scales.

• Patient who accepts enroll to the study.

Locations
Other Locations
Egypt
Faculty of Oral and Dental Medicine, Egyptian Russian University
RECRUITING
Cairo
Time Frame
Start Date: 2025-12-15
Estimated Completion Date: 2026-10
Participants
Target number of participants: 111
Treatments
Experimental: ibuprofen
Ibuprofen. a NSAID, will be ground and formed into a paste to be placed inside the root canals of necrotic mandibular posterior teeth, to explore its effects on post-operative pain
Experimental: nitrofurantoin
Active_comparator: calcium hydroxide
Related Therapeutic Areas
Sponsors
Leads: Cairo University
Collaborators: Egyptian Russian University, Fayoum University

This content was sourced from clinicaltrials.gov