Learn About Necrotizing Myopathy (NM)

What is the definition of Necrotizing Myopathy (NM)?
Necrotizing myopathy, also called necrotizing autoimmune myopathy, is a chronic inflammatory condition in which cell death occurs within the muscles. This cell death leads to degeneration of the muscle fibers, causing progressive muscle weakness.
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What are the symptoms of Necrotizing Myopathy (NM)?
Symptoms of necrotizing myopathy include fatigue; weight loss; fever; progressive muscle weakness in the forearms, thighs, hips, shoulders, neck, and back; muscle pain; joint pain and swelling; breathing difficulty; difficulty swallowing; heartburn; voice changes; difficulty getting up and standing; difficulty climbing stairs; falls; contractures around large joints; muscle wasting; and sensitivity to cold. Symptoms of necrotizing myopathy can come and go.
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What are the current treatments for Necrotizing Myopathy (NM)?
There is currently no cure for necrotizing myopathy. Treatment for necrotizing myopathy is focused on managing symptoms with the use of glucocorticoids; calcium and vitamin D supplements; immunosuppressive drugs such as methotrexate, azathioprine, mycophenolate mofetil, tacrolimus, cyclosporine cyclophosphamide, and intravenous immunoglobulin; biologic agents, such as monoclonal antibodies, and rituximab; physical therapy; speech therapy; and nutritional therapy.
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What are the latest Necrotizing Myopathy (NM) Clinical Trials?
High-intensity Strength Training in Patients With Idiopathic Inflammatory Myopathies: Changes in Quality of Life, Muscle Strength, Function and Myocellular Parameters

Summary: This study evaluates the effects of a high-intensity strength training in patients with myositis with the primary outcome being quality of life (SF-36). The study is designed as a parallel group randomised controlled trial with an intervention group and a control group.

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An Open Label Clinical Trial to Evaluate the Safety and Efficacy of CT103A Cells for the Treatment of Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System

Summary: Antibody-mediated idiopathic inflammatory diseases of the nervous system (also known as autoimmune diseases of the nervous system) are autoimmune diseases in which autoimmune cells and immune molecules attack the nervous system as the main pathogenic mechanism. In the immune response, pathogenic antibodies acting on autoantigens of the nervous system are collectively referred to as autoantibodies ...

What are the Latest Advances for Necrotizing Myopathy (NM)?
Treatment of Dermatomyositis and Immune-Mediated Necrotizing Myopathy with Poor Muscle Recovery with Steroids and IVIg: Therapeutic Strategies for Refractory Inflammatory Myositis.
Belimumab for Immune-Mediated Necrotizing Myopathy Associated With Anti-SRP Antibodies: A Case Report and Retrospective Review of Patients Treated With Anti-B-Cell Therapy in a Single Center and Literature.
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Statin-Induced Autoimmune Necrotizing Myopathy.