Necrotizing Myopathy (NM) Overview

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Learn About Necrotizing Myopathy (NM)

What is the definition of Necrotizing Myopathy (NM)?
Necrotizing myopathy, also called necrotizing autoimmune myopathy, is a chronic inflammatory condition in which cell death occurs within the muscles. This cell death leads to degeneration of the muscle fibers, causing progressive muscle weakness.
What are the symptoms of Necrotizing Myopathy (NM)?
Symptoms of necrotizing myopathy include fatigue; weight loss; fever; progressive muscle weakness in the forearms, thighs, hips, shoulders, neck, and back; muscle pain; joint pain and swelling; breathing difficulty; difficulty swallowing; heartburn; voice changes; difficulty getting up and standing; difficulty climbing stairs; falls; contractures around large joints; muscle wasting; and sensitivity to cold. Symptoms of necrotizing myopathy can come and go.
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What are the current treatments for Necrotizing Myopathy (NM)?
There is currently no cure for necrotizing myopathy. Treatment for necrotizing myopathy is focused on managing symptoms with the use of glucocorticoids; calcium and vitamin D supplements; immunosuppressive drugs such as methotrexate, azathioprine, mycophenolate mofetil, tacrolimus, cyclosporine cyclophosphamide, and intravenous immunoglobulin; biologic agents, such as monoclonal antibodies, and rituximab; physical therapy; speech therapy; and nutritional therapy.
Who are the top Necrotizing Myopathy (NM) Local Doctors?
Andrew L. Mammen
Elite in Necrotizing Myopathy (NM)
Dr. Andrew L. Mammen
Neuromusculoskeletal Medicine | Neurology
Elite in Necrotizing Myopathy (NM)
Dr. Andrew L. Mammen
Neuromusculoskeletal Medicine | Neurology

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue, Bayview Medical Offices, Level 01 (G), Clinic 5, Bayview Medical Offices, Level 01 (G), Clinic 5, 
Baltimore, MD 
Recognized by The Myositis Association
443-997-1552
Languages Spoken:
English
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Andrew Mammen is a Neuromusculoskeletal Medicine specialist and a Neurologist in Baltimore, Maryland. Dr. Mammen is rated as an Elite provider by MediFind in the treatment of Necrotizing Myopathy (NM). His top areas of expertise are Myositis, Polymyositis, Dermatomyositis, and Necrotizing Myopathy (NM).

Margherita Milone
Elite in Necrotizing Myopathy (NM)
Dr. Margherita Milone
Neurology
Elite in Necrotizing Myopathy (NM)
Dr. Margherita Milone
Neurology

MN - Neuro

200 1st St SW, 
Rochester, MN 
Recognized by The Myositis Association
507-512-1011
Languages Spoken:
English
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Offers Telehealth

Margherita Milone is a Neurologist in Rochester, Minnesota. Dr. Milone is rated as an Elite provider by MediFind in the treatment of Necrotizing Myopathy (NM). Her top areas of expertise are Progressive External Ophthalmoplegia, Necrotizing Myopathy (NM), Nemaline Myopathy, and Congenital Fiber-Type Disproportion.

 
 
 
 
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Don E. Adams
Advanced in Necrotizing Myopathy (NM)
Dr. Don E. Adams
Internal Medicine
Advanced in Necrotizing Myopathy (NM)
Dr. Don E. Adams
Internal Medicine

Cogent Healthcare Of Tennessee, PC

3209 Bristol Hwy, 
Johnson City, TN 
423-282-3311
Languages Spoken:
English
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Offers Telehealth

. Dr. Adams is rated as an Advanced provider by MediFind in the treatment of Necrotizing Myopathy (NM). His top areas of expertise are Heart Failure with Preserved Ejection Fraction (HFpEF), Necrotizing Myopathy (NM), Saddle Pulmonary Embolism, and Respiratory Syncytial Virus (RSV) Infection.

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What are the latest Necrotizing Myopathy (NM) Clinical Trials?
The MIGHT Trial - An Exploratory Clinical Trial of Intravenous Immunoglobulin (IVIG) in Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Immune Mediated Necrotizing Myopathy (IMNM)
The MIGHT Trial - An Exploratory Clinical Trial of Intravenous Immunoglobulin (IVIG) in Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Immune Mediated Necrotizing Myopathy (IMNM)
Enrollment Status: Recruiting
Publish Date: October 29, 2025
Intervention Type: Biological
Study Phase: Phase 2

Summary: This is a randomized, placebo-controlled, double blinded phase 2 exploratory clinical trial of intravenously administered pooled human immunoglobulin (IVIG) in anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune mediated necrotizing myopathy (IMNM). Planned enrollment is 12 individuals with active anti-HMGCR IMNM meeting inclusion and exclusion criteria. Assuming 20% drop-out, the investi...

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