Necrotizing Myopathy (NM)
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Learn About Necrotizing Myopathy (NM)

What is the definition of Necrotizing Myopathy (NM)?
Necrotizing myopathy, also called necrotizing autoimmune myopathy, is a chronic inflammatory condition in which cell death occurs within the muscles. This cell death leads to degeneration of the muscle fibers, causing progressive muscle weakness.
What are the symptoms of Necrotizing Myopathy (NM)?
Symptoms of necrotizing myopathy include fatigue; weight loss; fever; progressive muscle weakness in the forearms, thighs, hips, shoulders, neck, and back; muscle pain; joint pain and swelling; breathing difficulty; difficulty swallowing; heartburn; voice changes; difficulty getting up and standing; difficulty climbing stairs; falls; contractures around large joints; muscle wasting; and sensitivity to cold. Symptoms of necrotizing myopathy can come and go.
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What are the current treatments for Necrotizing Myopathy (NM)?
There is currently no cure for necrotizing myopathy. Treatment for necrotizing myopathy is focused on managing symptoms with the use of glucocorticoids; calcium and vitamin D supplements; immunosuppressive drugs such as methotrexate, azathioprine, mycophenolate mofetil, tacrolimus, cyclosporine cyclophosphamide, and intravenous immunoglobulin; biologic agents, such as monoclonal antibodies, and rituximab; physical therapy; speech therapy; and nutritional therapy.
Who are the top Necrotizing Myopathy (NM) Local Doctors?
Elite in Necrotizing Myopathy (NM)
Neuromusculoskeletal Medicine | Neurology
Elite in Necrotizing Myopathy (NM)
Neuromusculoskeletal Medicine | Neurology
Referral required

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue, Bayview Medical Offices, Level 01 (G), Clinic 5, Bayview Medical Offices, Level 01 (G), Clinic 5, 
Baltimore, MD 
Recognized by The Myositis Association
Languages Spoken:
English

Andrew Mammen is a Neuromusculoskeletal Medicine specialist and a Neurologist practicing medicine in Baltimore, Maryland. Dr. Mammen is rated as an Elite provider by MediFind in the treatment of Necrotizing Myopathy (NM). He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Myositis, Polymyositis, Dermatomyositis, and Necrotizing Myopathy (NM). Dr. Mammen is board certified in American Board Of Psychiatry And Neurology.

Elite in Necrotizing Myopathy (NM)
Elite in Necrotizing Myopathy (NM)
Referral required

MN - Neuro

200 1st St SW, 
Rochester, MN 
Recognized by The Myositis Association
Languages Spoken:
English
Offers Telehealth

Margherita Milone is a Neurologist practicing medicine in Rochester, Minnesota. Dr. Milone is rated as an Elite provider by MediFind in the treatment of Necrotizing Myopathy (NM). She is also highly rated in 36 other conditions, according to our data. Her clinical expertise encompasses Necrotizing Myopathy (NM), Nemaline Myopathy, Progressive External Ophthalmoplegia, and Tubular Aggregate Myopathy. Dr. Milone is board certified in MN State Medical License 2003-2023.

 
 
 
 
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Advanced in Necrotizing Myopathy (NM)
Internal Medicine | Pediatrics
Advanced in Necrotizing Myopathy (NM)
Internal Medicine | Pediatrics

Texas Health Family Care

5701 Bryant Irvin Road, Ste 201, 
Fort Worth, TX 
Languages Spoken:
English
Offers Telehealth

Charles Kwaw is a primary care provider, practicing in Internal Medicine and Pediatrics in Fort Worth, Texas. Dr. Kwaw is rated as an Advanced provider by MediFind in the treatment of Necrotizing Myopathy (NM). He is also highly rated in 15 other conditions, according to our data. His clinical expertise encompasses Type 2 Diabetes (T2D), Familial Combined Hyperlipidemia, Xanthoma, Cirrhosis, and Ureteroscopy.

What are the latest Necrotizing Myopathy (NM) Clinical Trials?
Study of Ublituximab in Early, Active, Autoantibody-Positive, IMMune-MedIated NecroTizing Myopathy (AIM01)

Summary: This is a multi-center, Phase 2 trial of ublituximab as first-line combination therapy in early, active autoantibody positive immune-mediated necrotizing myopathy. The primary objective is to estimate the effect of ublituximab as first add-on combination therapy at 24 weeks compared to placebo in treating early, active autoantibody positive immune-mediated necrotizing myopathy using the validated ...

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The MIGHT Trial - An Exploratory Clinical Trial of Intravenous Immunoglobulin (IVIG) in Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Immune Mediated Necrotizing Myopathy (IMNM)

Summary: This is a randomized, placebo-controlled, double blinded phase 2 exploratory clinical trial of intravenously administered pooled human immunoglobulin (IVIG) in anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune mediated necrotizing myopathy (IMNM). Planned enrollment is 12 individuals with active anti-HMGCR IMNM meeting inclusion and exclusion criteria. Assuming 20% drop-out, the investi...