Learn About Nelson Syndrome

What is the definition of Nelson Syndrome?
A rare, acquired, endocrine disease characterized by the triad of diffuse skin and mucosa hyperpigmentation, markedly elevated serum adrenocorticotropin (ACTH) levels and an enlarging corticotroph adenoma, which manifest following total bilateral adrenalectomy performed for the treatment of Cushing's disease. Additionally, patients may present with headaches, visual field defects, cranial nerve palsy, pituitary apoplexy, diabetes inspidus, panhypopituitarism, and, occasionally, paraovarian or paratesticular tumors.
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What are the alternative names for Nelson Syndrome?
  • Nelson syndrome
  • Dermal Ridges
  • Ridges-off-the-end syndrome
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What are the latest Nelson Syndrome Clinical Trials?
Long-Term Follow-UP of Survivors of Pediatric Cushing Disease

Background: The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems. Some of these problems might persist after the disease is cured.

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Seoul National University Pituitary Disease Cohort Study

Summary: The purpose of this study is to investigate the treatment and natural history of pituitary disease. We have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. We will continue to follow patients and recruit new patients for treatment and follow-up. Blood and pituitary tumor tissue (when available through clinical car...

Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Nelson Syndrome?
Pasireotide-Induced Shrinkage in GH and ACTH Secreting Pituitary Adenoma: A Systematic Review and Meta-Analysis.
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
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