Analgesic Effect of Accelerated Repetitive Transcranial Magnetic Stimulation in Pain Related to Peripheral Neuropathy

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Peripheral neuropathy is a frequent condition, commonly associated with pain. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive method of modulation of brain plasticity and is regarded as one of alternative methods to alleviate pain associated with various kind of neuropathies. rTMS is usually performed once a day and the whole therapy of neuropathic pain lasts one week. In a number of recent clinical trials including patients with depression and some other disorders, rTMS was delivered several times a day, which reduced the time of the whole therapy. This approach was termed an accelerated rTMS. The purpose of this study is to investigate feasibility of accelerated rTMS in treatment of neuropathic pain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosis of peripheral neuropathy

• Neuropathic pain of constant severity since not less than a month and requiring use of analgesics more than once a week

• Score of 30 millimeter or more on the 100 millimeter visual analog scale of pain intensity at inclusion

Locations
Other Locations
Poland
Jagiellonian University Medical College
RECRUITING
Krakow
Contact Information
Primary
Jakub M Antczak, MD
jakub.antczak@uj.edu.pl
+48 795 421 153
Backup
Gabriela G Rusin, MD
gabriela.rusin@doctoral.uj.edu.pl
+48 601 661 607
Time Frame
Start Date: 2022-11-04
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 70
Treatments
Experimental: Active repetitive transcranial magnetic stimulation
10 hertz (Hz) rTMS will be administered over the primary motor area. Therapy will include 6 sessions (three sessions in two consecutive days). In every sessions 1500 magnetic pulses of 90% of the resting motor threshold intensity will be elicited.
Sham_comparator: Sham repetitive transcranial magnetic stimulation
Sham stimulation will mimic the active one except that the stimulating coil will be held perpendicularly to the scalp, which assures similar impression as the active stimulation but prevents that significant magnetic field will reach brain tissue.
Related Therapeutic Areas
Sponsors
Leads: Jakub Antczak

This content was sourced from clinicaltrials.gov