Targeted Spinal Cord Plasticity for Alleviating SCI-related Neuropathic Pain

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• neurologically stable (\>1 year post SCI)

• medical clearance to participate

• ability to stand with or without an assistive device for at least 3 minutes at a time

• expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)

• For participants with neuropathic pain, the area of neuropathic pain must include lower leg.

Locations
United States
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Blair Dellenbach, MSOT
stecb@musc.edu
843-792-6313
Time Frame
Start Date: 2023-03-27
Estimated Completion Date: 2026-10-01
Participants
Target number of participants: 15
Treatments
Experimental: Operant Conditioning of Cutaneous Reflexes
Each participant completes 6 baseline sessions and 30 conditioning sessions. In each of the 30 conditioning sessions, while the participant is standing nerves in the lower leg and ankle are stimulated to activate the reflex. The participant attempts to change the reflex activity based on visual feedback. In this way the cutaneous reflex (skin reflex) will be changed to decrease neuropathic pain resulting from spinal cord injury.
Related Therapeutic Areas
Sponsors
Leads: Medical University of South Carolina
Collaborators: United States Department of Defense

This content was sourced from clinicaltrials.gov