Response Profiles to High-concentration Capsaicin Desensitization in Patients with Peripheral Neuropathic Pain with or Without Allodynia: a Regional Multicenter Prospective Cohort
Prospective multicenter cohort to determine patient profiles (associated factors, including allodynia) with a better response to pain desensitization by capsaicin delivered in the form of a high concentration patch (8%), in a population of patients with peripheral neuropathic pain and followed up in a pain consultation in the Auvergne Rhône Alpes region.
• Patient over 18 years of age on the day of inclusion
• Patient who has been informed and has not expressed opposition to participating in the study,
• Patient with peripheral neuropathic pain (whatever the etiology), defined by :
‣ Neuropathic Pain 4 score (DN4 score) ≥ 4/10
⁃ AND pain according to the numerical scale (EN) \> 4/10,
⁃ AND stable analgesic treatment for at least 1 month,
⁃ AND with or without mechanical allodynia according to the Quantitative Sensory Testing (QST) : Brush test (dynamic), Von Frey test (static)
⁃ AND with or without thermal allodynia to hot or cold as determined by a ROLLTEMP-II® (Rolltemp is a device designed for quick screening of temperature sensibility over large body areas).
• Patient responding to an indication of desensitization to high concentration capsaicin concentration and not presenting any contra-indication.
• Patient naïve of high concentration of Capsaicin on the concerned zone
• Patient understanding French