Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS \> 3) persisting beyond the expected healing period. This investigator-initiated, descriptive cohort study will re-invite approximately 100 consenting patients with persistent postoperative pain-identified from a pool of \ 7 000 respondents-to complete standardized assessments of neuropathic (DN4), nociplastic (IASP criteria + Fibromyalgia Survey Questionnaire) and nociceptive (KOOS/HOOS pain domains) pain. Primary outcomes are the prevalence of potential nociplastic pain and the proportion experiencing significant pain in two or more mechanistic categories. Secondary analyses will compare baseline vs. re-evaluated DN4 scores, FSQ and KOOS/HOOS distributions, and examine differences between patients with and without possible neuropathic pain. Findings will inform targeted pre- and postoperative pain management strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• All patients with persistent moderate-severe pain (NRS\>3) after THA, TKA and UKA

• Acceptance to be contacted.

Locations
Other Locations
Denmark
Rigshospitalet
RECRUITING
Østerbro
Contact Information
Primary
Milan Mohammad, MD
milanmohammad@hotmail.com
+4560162372
Time Frame
Start Date: 2025-06-26
Estimated Completion Date: 2026-03-01
Participants
Target number of participants: 100
Treatments
Persistant pain (NRS above 3)
Explore the pain composition in terms of neuropathic, nociceptive and nociplastic pain in patients with persistent pain after total knee arthroplasty (TKA), total hip arthroplasty (THA), or unicompartmental knee arthroplasty (UKA).
Sponsors
Collaborators: Bispebjerg Hospital
Leads: Rigshospitalet, Denmark

This content was sourced from clinicaltrials.gov