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Pain Alleviation for Patients Receiving Directional Deep Brain Stimulation to Treat Neuropathic Dental Pain

Status: Recruiting

Location: See location...

Intervention Type: Device

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This prospective observational study will evaluate pain outcomes in patients with neuropathic dental pain (Atypical Odontalgia/Phantom Tooth Pain) who undergo directional deep brain stimulation (DBS). Participants will complete validated pain, disability, quality-of-life, and mood assessments before surgery and following DBS programming. Directional stimulation will be applied to different thalamic targets to determine whether specific stimulation settings are associated with greater pain relief. The study aims to characterize changes in pain and quality of life following DBS and to identify the stimulation target associated with the greatest reduction in neuropathic dental pain.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 19

Maximum Age: 80

Healthy Volunteers: f

View:

• Age 19 to 80 years.

• Diagnosis of Atypical Odontalgia (AO) (also known as neuropathic dental pain).

• Receiving deep brain stimulation (DBS) treatment for AO due to inadequate response to conventional therapies, including: Pharmacological therapies, and/or Local anesthetics, corticosteroid injections, or nerve blocks.

• Able and willing to provide informed consent.

Locations

Other Locations

Canada

Vancouver General Hospital

RECRUITING

Vancouver

Contact Information

Primary

Danielle Pietramala

danielle.pietram@ubc.ca

604-875-4111

Time Frame

Start Date: 2026-01-01

Estimated Completion Date: 2028-01-01

Participants

Target number of participants: 5

Treatments

Experimental: Ring-Mode Stimulation

Participants receive DBS ring-mode stimulation, allowing current to spread across the target region encompassing the ventral posteromedial nucleus (VPM), anterior pulvinar (aPu), and centromedian nucleus (CM).

Experimental: Ventral Posteromedial Nucleus (VPM) Stimulation

Participants receive directional DBS stimulation targeted toward the ventral posteromedial nucleus (VPM) of the thalamus.

Experimental: Anterior Pulvinar (aPu) Stimulation

Participants receive directional DBS stimulation targeted toward the anterior pulvinar (aPu) of the thalamus.

Experimental: Centromedian Nucleus (CM) Stimulation

Participants receive directional DBS stimulation targeted toward the centromedian nucleus (CM) of the thalamus.

No_intervention: Stimulation Off

Participants have the DBS device turned off and serve as a control condition for comparison with active stimulation settings.

Related Therapeutic Areas

Neuralgia

Deep Brain Stimulation

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