Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient ≥ 18 years old
• Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
• Informed consent obtained
• Patients with a french social protection (AME excluded)
Locations
Other Locations
France
Hôpital de Bicêtre
RECRUITING
Le Kremlin-bicêtre
Hôpital Pitié-Salpétrière
RECRUITING
Paris
Contact Information
Primary
Ghizlene Lahlou
ghizlene.lahlou@pasteur.fr
33 1 45688891
Backup
Saaid Safieddine
saaid.safieddine@pasteur.fr
Time Frame
Start Date: 2019-02-19
Estimated Completion Date: 2027-02-18
Participants
Target number of participants: 100
Treatments
AAV viral transduction
Collection of inner ear cells during a non-conservative surgical approach (translabyrinthine or transotic).
Related Therapeutic Areas
Sponsors
Collaborators: Assistance Publique - Hôpitaux de Paris
Leads: Institut Pasteur