Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age from 18 to 75 years;
• With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy;
• With tumor size ≤10 mm assessed by colonoscopy or EUS;
• Plan to receive UEMR or ESD treatment and provide written informed consent.
Locations
Other Locations
China
Nanfang Hospital, Southern Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Zelong Han, MD
hanzelong2025@163.com
+86 20-6278-7385
Backup
Bitao Lin, MD
linbitao1996@163.com
+86 137-2532-1385
Time Frame
Start Date: 2026-04-14
Estimated Completion Date: 2029-12
Participants
Target number of participants: 174
Treatments
Experimental: UEMR group
In UEMR group, enrolled patients will receive UEMR to remove small rectal NET.
Active_comparator: ESD group
In ESD group, enrolled patients will receive the standard treatment modality of ESD to remove small rectal NET
Related Therapeutic Areas
Sponsors
Collaborators: the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai), Ganzhou City People's Hospital, Jiangmen Central Hospital, Shenzhen Longgang District People's Hospital, Yangjiang People's Hospital, The Third People's Hospital of Huizhou, Guangdong Provincial Hospital of Traditional Chinese Medicine, ZhuHai Hospital, The Eighth Affiliated Hospital of Southern Medical University
Leads: Nanfang Hospital, Southern Medical University