Learn About Neurohypophyseal Diabetes Insipidus

What is the definition of Neurohypophyseal Diabetes Insipidus?

Neurohypophyseal diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with neurohypophyseal diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected people need to urinate frequently, which can disrupt daily activities and sleep.

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What are the causes of Neurohypophyseal Diabetes Insipidus?

The familial form of neurohypophyseal diabetes insipidus is caused by mutations in the AVP gene. This gene provides instructions for making a hormone called vasopressin or antidiuretic hormone (ADH). This hormone, which is produced and stored in the brain, helps control the body's water balance.

How prevalent is Neurohypophyseal Diabetes Insipidus?

Neurohypophyseal diabetes insipidus is thought to be rare, although its exact incidence is unknown. The acquired form occurs much more frequently than the familial form.

Is Neurohypophyseal Diabetes Insipidus an inherited disorder?

Familial neurohypophyseal diabetes insipidus is almost always inherited in an autosomal dominant pattern, which means one copy of the altered AVP gene in each cell is sufficient to cause the disorder.

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Who are the sources who wrote this article ?

Published Date: April 01, 2010Published By: National Institutes of Health

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