Neuronal Intranuclear Inclusion Disease (NIID)
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Neuronal Intranuclear Inclusion Disease (NIID) Overview

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Learn About Neuronal Intranuclear Inclusion Disease (NIID)

What is the definition of Neuronal Intranuclear Inclusion Disease (NIID)?
Neuronal intranuclear inclusion disease (NIID) is a slowly progressive, neurodegenerative disease. NIID may affect any part of the nervous system (central, peripheral, and/or autonomic), as well as various organs. Therefore, people with NIID may have impairment of balance, movement, cognition, communication, behavior, and the ability to function independently. In general, limb weakness and ataxia are more common in children with NIID, while dementia is more common in people diagnosed in adulthood. The features of NIID result from the presence of eosinophilic intranuclear inclusions inside neurons and glial cells (abnormal masses of substances in the nuclei of cells of the nervous system). Recently, a genetic change in the NOTCH2NLC gene has been found to cause NIID.
What are the alternative names for Neuronal Intranuclear Inclusion Disease (NIID)?
  • Neuronal intranuclear inclusion disease
  • NIID
  • Neuronal intranuclear hyaline inclusion disease
Who are the top Neuronal Intranuclear Inclusion Disease (NIID) Local Doctors?
Distinguished in Neuronal Intranuclear Inclusion Disease (NIID)
Distinguished in Neuronal Intranuclear Inclusion Disease (NIID)
Referral may be required

Neurological Sciences Center At Clarkson Doctors Building North

4242 Farnam St., Suite 650, 
Omaha, NE 
402-559-8600
Languages Spoken:
English, American Sign Language
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Accepting New Patients
Offers Telehealth

Daniel Murman is a Neurologist practicing medicine in Omaha, Nebraska. Dr. Murman is rated as a Distinguished provider by MediFind in the treatment of Neuronal Intranuclear Inclusion Disease (NIID). He is also highly rated in 19 other conditions, according to our data. His clinical expertise encompasses Alzheimer's Disease, Dementia, Primary Progressive Aphasia, and Frontotemporal Dementia. Dr. Murman is currently accepting new patients.

Elite in Neuronal Intranuclear Inclusion Disease (NIID)
Elite in Neuronal Intranuclear Inclusion Disease (NIID)
Referral may be required
Okayama, JP 

Hiroyuki Ishiura practices practicing medicine in Okayama, Japan. Mr. Ishiura is rated as an Elite expert by MediFind in the treatment of Neuronal Intranuclear Inclusion Disease (NIID). He is also highly rated in 42 other conditions, according to our data. His clinical expertise encompasses Neuronal Intranuclear Inclusion Disease (NIID), Paraplegia, Spastic Paraplegia Type 7, Thalamotomy, and Bone Marrow Transplant.

 
 
 
 
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Elite in Neuronal Intranuclear Inclusion Disease (NIID)
Elite in Neuronal Intranuclear Inclusion Disease (NIID)
Referral may be required
Crest, 
Kawaguchi, JP 

Naomichi Matsumoto practices practicing medicine in Kawaguchi, Japan. Matsumoto is rated as an Elite expert by MediFind in the treatment of Neuronal Intranuclear Inclusion Disease (NIID). They are also highly rated in 148 other conditions, according to our data. Their clinical expertise encompasses West Syndrome, Coffin-Siris Syndrome, Neuronal Intranuclear Inclusion Disease (NIID), Pancreaticoduodenectomy, and Gastrostomy.

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What are the latest Neuronal Intranuclear Inclusion Disease (NIID) Clinical Trials?
Effect of NOTCH2NLC Gene Variations on NIID Clinical Features
Effect of NOTCH2NLC Gene Variations on NIID Clinical Features
Enrollment Status: Recruiting
Publish Date: June 26, 2026
Intervention Type: Other

Summary: This study aims to understand how differences in the NOTCH2NLC gene affect the symptoms and course of neuronal intranuclear inclusion disease (NIID), a rare inherited neurological disorder. NIID is caused by an abnormal expansion of a GGC DNA repeat in the NOTCH2NLC gene, but members of the same family can have very different repeat sizes and patterns, leading to a wide variety of problems-such as...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center