Learn About Nevoid Basal Cell Carcinoma Syndrome

What is the definition of Nevoid Basal Cell Carcinoma Syndrome?

Nevoid basal cell carcinoma syndrome is a group of conditions passed down through families. The disorder involves the skin, nervous system, eyes, endocrine glands, urinary and reproductive systems, and bones.

It causes an unusual facial appearance and a higher risk for skin cancers and noncancerous tumors.

What are the alternative names for Nevoid Basal Cell Carcinoma Syndrome?

NBCC syndrome; Gorlin syndrome; Gorlin-Goltz syndrome; Basal cell nevus syndrome (BCNS); Basal cell cancer - nevoid basal cell carcinoma syndrome

What are the causes of Nevoid Basal Cell Carcinoma Syndrome?

Nevoid basal cell carcinoma syndrome is a rare genetic condition. The main gene linked to the syndrome is known as PTCH (patched). A second gene, called SUFU, has also been associated with this condition.

Variations in these genes are most commonly passed down through families as an autosomal dominant trait. This means you develop the syndrome if either parent passes the gene to you. If either of your parents has this syndrome, you have a 50% chance of having it. It is also possible to develop this gene variation with no family history.

What are the symptoms of Nevoid Basal Cell Carcinoma Syndrome?

Main symptoms of this disorder are:

  • A type of skin cancer called basal cell carcinoma that develops around the time of puberty
  • A noncancerous tumor of the jaw, called keratocystic odontogenic tumor that also develops during puberty

Other symptoms include:

  • Broad nose
  • Cleft palate
  • Heavy, protruding brow
  • Jaw that sticks out (in some cases)
  • Wide-set eyes
  • Pitting on palms and soles

The condition may affect the nervous system and lead to:

  • Eye problems
  • Deafness
  • Intellectual disability
  • Seizures
  • Tumors of the brain

The condition also leads to bone defects, including:

  • Curvature of the back (scoliosis)
  • Severe curvature of the back (kyphosis)
  • Abnormal ribs
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What are the current treatments for Nevoid Basal Cell Carcinoma Syndrome?

It is important to get examined by a skin specialist (dermatologist) often, so that skin cancers may be treated while they are still small.

People with this disorder may also be seen and treated by other specialists, depending on which part of the body is affected. For example, a cancer specialist (oncologist) may treat tumors in the body, and an orthopedic surgeon may help treat bone problems.

Who are the top Nevoid Basal Cell Carcinoma Syndrome Local Doctors?
Giovanni Ponti
Elite in Nevoid Basal Cell Carcinoma Syndrome
Elite in Nevoid Basal Cell Carcinoma Syndrome
Modena, IT 

Giovanni Ponti practices in Modena, Italy. Ponti and is rated as an Elite expert by MediFind in the treatment of Nevoid Basal Cell Carcinoma Syndrome. His top areas of expertise are Nevoid Basal Cell Carcinoma Syndrome, Basal Cell Skin Cancer, Multiple Familial Trichoepithelioma, and Melanoma.

Elite in Nevoid Basal Cell Carcinoma Syndrome
Elite in Nevoid Basal Cell Carcinoma Syndrome
Manchester, ENG, GB 

John Lear practices in Manchester, United Kingdom. Lear and is rated as an Elite expert by MediFind in the treatment of Nevoid Basal Cell Carcinoma Syndrome. His top areas of expertise are Basal Cell Skin Cancer, Nevoid Basal Cell Carcinoma Syndrome, Actinic Keratosis, and Squamous Cell Skin Carcinoma.

 
 
 
 
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Elite in Nevoid Basal Cell Carcinoma Syndrome
Elite in Nevoid Basal Cell Carcinoma Syndrome
400 30th St, Suite 205, 
Oakland, CA 
Languages Spoken:
English

Ervin Epstein is a Dermatologist in Oakland, California. Dr. Epstein and is rated as an Elite provider by MediFind in the treatment of Nevoid Basal Cell Carcinoma Syndrome. His top areas of expertise are Nevoid Basal Cell Carcinoma Syndrome, Basal Cell Skin Cancer, Intertrigo, and Carney Complex.

What is the outlook (prognosis) for Nevoid Basal Cell Carcinoma Syndrome?

Frequent follow-up with a variety of specialists is important for having a good outcome.

What are the possible complications of Nevoid Basal Cell Carcinoma Syndrome?

People with this condition may develop:

  • Blindness
  • Brain tumor
  • Deafness
  • Fractures
  • Ovarian tumors
  • Cardiac fibromas
  • Skin damage and severe scarring due to skin cancers
When should I contact a medical professional for Nevoid Basal Cell Carcinoma Syndrome?

Contact your health care provider if:

  • You or any family members have nevoid basal cell carcinoma syndrome, especially if you are planning to have a child.
  • You have a child who has symptoms of this disorder.
How do I prevent Nevoid Basal Cell Carcinoma Syndrome?

Couples with a family history of this syndrome might consider genetic counseling before becoming pregnant.

Staying out of the sun and using sunscreen can help prevent new basal cell skin cancers.

Avoid radiation such as x-rays. People with this condition are very sensitive to radiation. Exposure to radiation can lead to skin cancers.

What are the latest Nevoid Basal Cell Carcinoma Syndrome Clinical Trials?
Familial Investigations of Childhood Cancer Predisposition

Summary: NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility...

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Registration of Oral Hedgehog Inhibitors Vismodegib and Sonidegib in the Treatment of Advanced and Multiple Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study.

Background: Oral hedgehog inhibitors vismodegib and sonidegib have been used for the treatment of locally advanced (laBCC), metastatic basal cell carcinoma (mBCC) and in basal cell nevus syndrome (BCNS) patients. In the Netherlands, targeted therapy with vismodegib and sonidegib has been available since 2013 and 2021, respectively. No direct comparative studies have been performed between the two oral hedgeho...

Who are the sources who wrote this article ?

Published Date: May 28, 2024
Published By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Epstein EH. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). In: Lebwohl MG, Heymann WR, Coulson IH, Murrell DF, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 170.

Martin KL. Tumors of the skin. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 711.

Walsh MF, Cadoo K, Salo-Mullen EE, Dubard-Gault M, Stadler ZK, Offit K. Genetic factors: hereditary cancer predisposition syndromes. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 13.