Learn About New Daily Persistent Headache (NDPH)

View Main Condition: Headache

What is the definition of New Daily Persistent Headache (NDPH)?
New daily persistent headache (NDPH) is a rare headache syndrome that starts abruptly and is characterized by a continuing headache that lasts without relief for at least 24 hours, usually becoming constant within 3 days, and occurring for at least fifteen days a month for a period of one month. This headache syndrome mainly affects patients without a previous history of headache and is often resistant to treatment. Unlike many other types or headaches, patients often characteristically remember exactly when the headache started.
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What are the symptoms of New Daily Persistent Headache (NDPH)?
Symptoms of new daily persistent headache include a headache that starts abruptly that affects both sides of the head (bilateral), and mild to moderate pain that feels like pressure or a tightening (non-pulsating) that can be continuous or may come and go. This headache syndrome may further have symptoms characteristic of chronic migraines or tension headaches, such as photophobia (light sensitivity), phonophobia (sound sensitivity), and nausea or vomiting. Additional (comorbid) symptoms may include light-headedness, sleep problems, concentration problems, blurred vision, numbness, tingling, vertigo, fatigue, and mood disorders, such as severe anxiety and depression.
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What are the current treatments for New Daily Persistent Headache (NDPH)?
Treatment for new daily persistent headache usually begins with treating an underlying condition that may be causing the headaches. However, this headache syndrome often remains resistant to treatment (refractory), in which case treatment focuses on preventing and alleviating pain. Medications for new daily persistent headache include antidepressants, such as nortriptyline (Pamelor); selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac, Sarafem, or others); beta blockers, such as atenolol (Tenormin), metoprolol (Lopressor, Toprol-XL), and propranolol (Inderal, Innopram XL); anti-seizure medications, such as topiramate (Topamax, Qudexy XR), divalproex sodium (Depakote), and gabapentin (Neurontin, Gralise); non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen sodium (Anaprox, Naprelan); botulinum toxin (Onabotulinum toxin A ); and tetracycline derivatives, such as doxycycline. Combined drug therapies may also be used, such as nortriptyline and topiramate; gabapentin and topiramate; clonazepam, botulinum toxin A, and mexiletine; doxycycline and montelukast; or intravenous methylprednisolone, intravenous sodium valproate, anti-depressants (amitriptyline or dothiepin), and naproxene. Treatments for patients who do not respond to prophylactic (preventive) drugs include peripheral nerve blocks with 0.5% bupivacaine, ketamine infusion, intravenous lidocaine, intravenous methylprednisolone, and osteopathic manipulation therapy.
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What are the latest New Daily Persistent Headache (NDPH) Clinical Trials?
China HeadAche DIsorders RegiStry

Summary: It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS), patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected. The biomarkers, imaging features, cognition, genetic characteristics, ocial and demographic data, medical data, therapeutics used, and outcome of headache-related diseases were studied, and long-term follow...

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Prospective Observational Pilot Study of Low-dose Naltrexone in Patients With Chronic Migraine With Comorbid Fibromyalgia

Summary: This research aims to look at the effect of low-dose naltrexone on the severity and frequency of attacks in people with chronic migraine with or without new daily persistent headache and fibromyalgia. A few studies suggest low-dose naltrexone is effective for fibromyalgia, but it has not been studied in patients with migraine and headaches. Our goal is to see if there is an improvement in either s...

What are the Latest Advances for New Daily Persistent Headache (NDPH)?
Dihydroergotamine infusion for pediatric refractory headache: A retrospective chart review.
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Nutcracker syndrome mimicking new daily persistent headache: A case report.