A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Who is this study for? Patients with relapsed/refractory marginal zone lymphoma
What treatments are being studied? Zanubrutinib+Rituximab
Status: Recruiting
Location: See all (257) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Histologically confirmed grade 1-3a FL or MZL
• Previously treated with ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
• Need for systemic therapy for FL or MZL
• Measurable disease by computed tomography or magnetic resonance imaging
• Adequate bone marrow, liver and renal function
Locations
United States
California
Ucsf Fresno University of California San Francisco Fresno
ACTIVE_NOT_RECRUITING
Fresno
Cancer and Blood Specialty Clinic
ACTIVE_NOT_RECRUITING
Los Alamitos
Los Angeles Cancer Network
ACTIVE_NOT_RECRUITING
Los Angeles
Valkyrie Clinical Trials
ACTIVE_NOT_RECRUITING
Los Angeles
Sharp Healthcare Sharp Memorial Hospital
ACTIVE_NOT_RECRUITING
San Diego
Florida
Baptist Md Anderson Cancer Center
ACTIVE_NOT_RECRUITING
Jacksonville
Georgia
Northwest Georgia Oncology Centers Marietta
ACTIVE_NOT_RECRUITING
Marietta
Iowa
Mission Cancer and Blood
ACTIVE_NOT_RECRUITING
Waukee
Indiana
Fort Wayne Medical Oncology and Hematology
ACTIVE_NOT_RECRUITING
Fort Wayne
Kansas
Cancer Center of Kansas
ACTIVE_NOT_RECRUITING
Wichita
Kentucky
Baptist Health Lexington
ACTIVE_NOT_RECRUITING
Lexington
Louisiana
Christus Highland Cancer Treatment Center
ACTIVE_NOT_RECRUITING
Shreveport
Maryland
University of Maryland Greenebaum Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING
Baltimore
American Oncology Partners of Maryland Pa
ACTIVE_NOT_RECRUITING
Bethesda
Michigan
Henry Ford Hospital
ACTIVE_NOT_RECRUITING
Detroit
Corewell Health the Michigan Cancer Consortium
ACTIVE_NOT_RECRUITING
Grand Rapids
Missouri
University of Missouri Hospital, Ellis Fischel Cancer Center
ACTIVE_NOT_RECRUITING
Columbia
Oncology Hematology Associates
ACTIVE_NOT_RECRUITING
Springfield
Mississippi
Hattiesburg Hematology and Oncology Clinic
ACTIVE_NOT_RECRUITING
Hattiesburg
North Carolina
Levine Cancer Institute Wake Forest
ACTIVE_NOT_RECRUITING
Charlotte
Nebraska
Nebraska Cancer Specialists
ACTIVE_NOT_RECRUITING
Omaha
New Jersey
Iyengar Hematology Oncology Medical Center Pa
ACTIVE_NOT_RECRUITING
Bayonne
New York
New York Cancer and Blood Specialists
ACTIVE_NOT_RECRUITING
East Setauket
Clinical Research Alliance, Inc
ACTIVE_NOT_RECRUITING
Westbury
Pennsylvania
Cancer Care Associates of York
ACTIVE_NOT_RECRUITING
York
South Dakota
Prairie Lakes Healthcare System
ACTIVE_NOT_RECRUITING
Watertown
Texas
Texas Oncology Baylorcharles A Sammons Cancer Center
ACTIVE_NOT_RECRUITING
Dallas
Md Anderson Cancer Center
ACTIVE_NOT_RECRUITING
Houston
Northeast Texas Cancer and Research Institute
ACTIVE_NOT_RECRUITING
Tyler
Washington
University of Washington
ACTIVE_NOT_RECRUITING
Seattle
Northwest Medical Specialties
ACTIVE_NOT_RECRUITING
Tacoma
Other Locations
Argentina
Hospital Aleman
ACTIVE_NOT_RECRUITING
Caba
Hospital Italiano de Buenos Aires
ACTIVE_NOT_RECRUITING
Ciudad Autonoma Buenos Aires
Australia
Sunshine Coast Hospital and Health Service
COMPLETED
Birtinya
Monash Health
ACTIVE_NOT_RECRUITING
Clayton
Concord Repatriation General Hospital
ACTIVE_NOT_RECRUITING
Concord
Townsville University Hospital
ACTIVE_NOT_RECRUITING
Douglas
Epworth Freemasons
ACTIVE_NOT_RECRUITING
East Melbourne
St Vincents Hospital Melbourne
ACTIVE_NOT_RECRUITING
Fitzroy
Gosford Hospital
ACTIVE_NOT_RECRUITING
Gosford
Austin Health
ACTIVE_NOT_RECRUITING
Heidelberg
St George Hospital
ACTIVE_NOT_RECRUITING
Kogarah
Cabrini Hospital Malvern
ACTIVE_NOT_RECRUITING
Malvern East
La Trobe Regional Hospital
ACTIVE_NOT_RECRUITING
Melbourne
The Alfred Hospital
ACTIVE_NOT_RECRUITING
Melbourne
Genesiscare North Adelaide
ACTIVE_NOT_RECRUITING
North Adelaide
Orange Health Hospital
ACTIVE_NOT_RECRUITING
Orange
Royal Perth Hospital
ACTIVE_NOT_RECRUITING
Perth
Port Macquarie Base Hospital
ACTIVE_NOT_RECRUITING
Port Macquarie
Perth Blood Institute
ACTIVE_NOT_RECRUITING
West Perth
Westmead Hospital
ACTIVE_NOT_RECRUITING
Westmead
Austria
Medizinische Universitatsklinik Innsbruck
ACTIVE_NOT_RECRUITING
Innsbruck
Uk St Poelten
ACTIVE_NOT_RECRUITING
Sankt Pölten
Hanusch Krankenhaus
ACTIVE_NOT_RECRUITING
Vienna
Medical Univeristy Vienna
ACTIVE_NOT_RECRUITING
Vienna
Wiener Gesundheitsverbund Klinik Ottakring
ACTIVE_NOT_RECRUITING
Vienna
Belgium
Institut Jules Bordet
ACTIVE_NOT_RECRUITING
Anderlecht
Az Sint Jan Brugge
ACTIVE_NOT_RECRUITING
Bruges
Universitair Ziekenhuis Gent
ACTIVE_NOT_RECRUITING
Ghent
University Hospitals Leuven
ACTIVE_NOT_RECRUITING
Leuven
Brazil
Hospital de Amor Barretos
ACTIVE_NOT_RECRUITING
Barretos
Clinica de Oncologia Reichow
ACTIVE_NOT_RECRUITING
Blumenau
Unesp Faculdade de Medicina Da Universidade Estadual Paulista Campus Botucatu
ACTIVE_NOT_RECRUITING
Botucatu
Instituto Dor de Pesquisa E Ensino Distrito Federal
ACTIVE_NOT_RECRUITING
Brasília
Universidade de Campinas Centro de Hematologia E Hemoterapia
ACTIVE_NOT_RECRUITING
Campinas
Fundacao Universidade de Caxias Do Sul
ACTIVE_NOT_RECRUITING
Caxias Do Sul
Centro Integrado de Oncologia de Curitiba Ss Cionc
ACTIVE_NOT_RECRUITING
Curitiba
Hospital Erasto Gaertner
ACTIVE_NOT_RECRUITING
Curitiba
Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)
ACTIVE_NOT_RECRUITING
Florianópolis
Complexo Hospitalar de Niteroi
ACTIVE_NOT_RECRUITING
Niterói
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
ACTIVE_NOT_RECRUITING
Porto Alegre
Instituto Dor de Pesquisa E Ensino
ACTIVE_NOT_RECRUITING
Recife
Instituto Dor de Pesquisa E Ensino Pernambuco
ACTIVE_NOT_RECRUITING
Recife
Hospital Das Clinicas Da Faculdade de Medicina de Ribeirao Preto Usp
ACTIVE_NOT_RECRUITING
Ribeirão Preto
Instituto Americas Ensino, Pesquisa E Inovacao
ACTIVE_NOT_RECRUITING
Rio De Janeiro
Ensino E Terapia de Inovacao Clinica Amo Etica
ACTIVE_NOT_RECRUITING
Salvador
Hospital Sao Rafaelinstituto Dor de Pesquisa E Ensino
ACTIVE_NOT_RECRUITING
Salvador
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
ACTIVE_NOT_RECRUITING
São Paulo
Hospital Nove de Julho Dasa
ACTIVE_NOT_RECRUITING
São Paulo
Instituto Dor de Pesquisa E Ensino Sao Paulo
ACTIVE_NOT_RECRUITING
São Paulo
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
ACTIVE_NOT_RECRUITING
São Paulo
Hospital Santa Rita de Cassia Afecc
ACTIVE_NOT_RECRUITING
Vitória
Bulgaria
Umhat Svgeorgi Ead
COMPLETED
Plovdiv
Acibadem City Clinic Tokuda Umhat Ead, Department of Medical Oncology
ACTIVE_NOT_RECRUITING
Sofia
NHATHD
ACTIVE_NOT_RECRUITING
Sofia
University Multiprofile Hospital For Active Treatment Saint Ivan Rilski
COMPLETED
Sofia
Canada
Ciusss Du Saguenay Lac St Jean
ACTIVE_NOT_RECRUITING
Chicoutimi
Queen Elizabeth Ii Health Sciences Centre
ACTIVE_NOT_RECRUITING
Halifax
Juravinski Cancer Centre
ACTIVE_NOT_RECRUITING
Hamilton
Centre Integre de Sante Et de Services Sociaux de Chaudiere Appalaches
ACTIVE_NOT_RECRUITING
Lévis
London Health Sciences Centre
ACTIVE_NOT_RECRUITING
London
Ciusss de Lest de Lile de Montreal Hopital Maisonneuve Rosemont
ACTIVE_NOT_RECRUITING
Montreal
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
ACTIVE_NOT_RECRUITING
Québec
Unite de Recherche Clinique Du Cisss Des Laurentides
ACTIVE_NOT_RECRUITING
Saintjerome
Ciusss de Lestrie Chus
ACTIVE_NOT_RECRUITING
Sherbrooke
Newfoundland and Labrador Health Services
ACTIVE_NOT_RECRUITING
St. John's
British Columbia Cancer Agency the Vancouver Centre
ACTIVE_NOT_RECRUITING
Vancouver
China
Anyang Tumor Hospital
ACTIVE_NOT_RECRUITING
Anyang
Beijing Cancer Hospital
ACTIVE_NOT_RECRUITING
Beijing
Beijing Friendship Hospital, Capital Medical University
ACTIVE_NOT_RECRUITING
Beijing
Beijing Friendship Hospital, Capital Medical University(Tongzhou)
ACTIVE_NOT_RECRUITING
Beijing
The First Hospital of Jilin University
ACTIVE_NOT_RECRUITING
Changchun
The First Peoples Hospital of Changde City
ACTIVE_NOT_RECRUITING
Changde
West China Hospital, Sichuan University
ACTIVE_NOT_RECRUITING
Chengdu
Chongqing Cancer Hospital
ACTIVE_NOT_RECRUITING
Chongqing
Dongyang Peoples Hospital
ACTIVE_NOT_RECRUITING
Dongyang
The First Peoples Hospital of Foshan
ACTIVE_NOT_RECRUITING
Foshan
Fujian Medical University Union Hospital
COMPLETED
Fuzhou
Sun Yat Sen University Cancer Center
ACTIVE_NOT_RECRUITING
Guangzhou
Zhejiang Cancer Hospital
ACTIVE_NOT_RECRUITING
Hangzhou
Harbin Medical University Cancer Hospital
ACTIVE_NOT_RECRUITING
Harbin
Huizhou Central Peoples Hospital
COMPLETED
Huizhou
The First Hospital of Jiaxing
ACTIVE_NOT_RECRUITING
Jiaxing
Jinhua Municipal Central Hospital
ACTIVE_NOT_RECRUITING
Jinhua
Meizhou People Hospital
ACTIVE_NOT_RECRUITING
Meizhou
Jiangxi Province Cancer Hospital
ACTIVE_NOT_RECRUITING
Nanchang
The First Affiliated Hospital of Nanchang University Branch Donghu
ACTIVE_NOT_RECRUITING
Nanchang
The First Affiliated Hospital of Nanchang University Branch Xianghu
ACTIVE_NOT_RECRUITING
Nanchang
Jiangsu Province Hospital
COMPLETED
Nanjing
Affiliated Hospital of Nantong University
ACTIVE_NOT_RECRUITING
Nantong
Peoples Hospital of Rizhao
ACTIVE_NOT_RECRUITING
Rizhao
Fudan University Shanghai Cancer Center
ACTIVE_NOT_RECRUITING
Shanghai
Liaoning Cancer Hospital and Institute
ACTIVE_NOT_RECRUITING
Shenyang
Shengjing Hospital of China Medical University
ACTIVE_NOT_RECRUITING
Shenyang
The First Affiliated Hospital of Soochow University
ACTIVE_NOT_RECRUITING
Suzhou
The Second Affiliated Hospital of Shandong First Medical University
ACTIVE_NOT_RECRUITING
Taian
Shanxi Provincial Cancer Hospital
ACTIVE_NOT_RECRUITING
Taiyuan
The First Affiliated Hospital of Wenzhou Medical University
ACTIVE_NOT_RECRUITING
Wenzhou
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
ACTIVE_NOT_RECRUITING
Wuhan
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
COMPLETED
Wuhan
The First Affiliated Hospital of Wannan Medical College
COMPLETED
Wuhu
Wuxi Peoples Hospital
ACTIVE_NOT_RECRUITING
Wuxi
The First Affiliated Hospital of Xiamen University
ACTIVE_NOT_RECRUITING
Xiamen
Affiliated Hospital of Guangdong Medical University
COMPLETED
Zhanjiang
Henan Cancer Hospital
ACTIVE_NOT_RECRUITING
Zhengzhou
France
Hopital Prive Dantony, Departement Dhemathologie
ACTIVE_NOT_RECRUITING
Antony
Centre Hospitalier Le Mans
ACTIVE_NOT_RECRUITING
Le Mans
Chu Montpellier Hopital Saint Eloi
ACTIVE_NOT_RECRUITING
Montpellier
Hopital Larchet Chu Nice
ACTIVE_NOT_RECRUITING
Nice
Institut Curie
ACTIVE_NOT_RECRUITING
Paris
Necker University Hospital
ACTIVE_NOT_RECRUITING
Paris
Icans Institut de Cancerologie Strasbourg Europe
ACTIVE_NOT_RECRUITING
Strasbourg
Chu Nancy Hopital Brabois
ACTIVE_NOT_RECRUITING
Vandoeuvrelesnancy
Georgia
JSC VIAN
ACTIVE_NOT_RECRUITING
Kutaisi
Germany
Universitaetsklinikum Essen
COMPLETED
Essen
Universitaetsklinikum Ulm
COMPLETED
Ulm
Greece
University Hospital of Alexandroupolis
ACTIVE_NOT_RECRUITING
Alexandroupoli
Evaggelismos
ACTIVE_NOT_RECRUITING
Athens
General Hospital of Athens Alexandra
COMPLETED
Athens
University Hospital of Patra
ACTIVE_NOT_RECRUITING
Pátrai
Ireland
St Jamess Hospital
ACTIVE_NOT_RECRUITING
Dublin
University Hospital Waterford
ACTIVE_NOT_RECRUITING
Waterford
Israel
Assuta Ashdod Medical Center
ACTIVE_NOT_RECRUITING
Ashdod
Hadassah En Karem Medical Center
ACTIVE_NOT_RECRUITING
Jerusalem
Shaare Zedek Medical Center
ACTIVE_NOT_RECRUITING
Jerusalem
Rabin Medical Center
ACTIVE_NOT_RECRUITING
Petah Tikva
Chaim Sheba Medical Center
ACTIVE_NOT_RECRUITING
Ramat Gan
Assuta Medical Center
ACTIVE_NOT_RECRUITING
Tel Aviv
Sourasky Tel Aviv Medical Center
ACTIVE_NOT_RECRUITING
Tel Aviv
Italy
Cro Irccs Aviano
ACTIVE_NOT_RECRUITING
Aviano
Irccs Azienda Ospedaliero Universitaria Bologna
ACTIVE_NOT_RECRUITING
Bologna
Aou Careggi, Servizio Sanitario Toscana
ACTIVE_NOT_RECRUITING
Florence
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
ACTIVE_NOT_RECRUITING
Milan
Istituto Europeo Di Oncologia
ACTIVE_NOT_RECRUITING
Milan
Aou Maggiore Della Carita
ACTIVE_NOT_RECRUITING
Novara
Azienda Ospedaliera Di Padova
ACTIVE_NOT_RECRUITING
Padua
Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi
ACTIVE_NOT_RECRUITING
Pavia
Arcispedale S Maria Nuova Ausl Reggio Emilia Hematology Unit
ACTIVE_NOT_RECRUITING
Reggio Emilia
Aou Santa Maria Della Misericordia Di Udine
ACTIVE_NOT_RECRUITING
Udine
Ospedale Di Circolo E Fondazione Macchi
ACTIVE_NOT_RECRUITING
Varese
Japan
Tokyo Metropolitan Komagome Hospital
NOT_YET_RECRUITING
Bunkyoku
Chiba Cancer Center
RECRUITING
Chiba
National Cancer Center Hospital
RECRUITING
Chuoku
Kansai Medical University Hospital
RECRUITING
Hirakata
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
RECRUITING
Hiroshima
Kagoshima University Hospital
NOT_YET_RECRUITING
Kagoshima
Cancer Institute Hospital of Jfcr
RECRUITING
Kotoku
Kumamoto University Hospital
RECRUITING
Kumamoto
Kurashiki Central Hospital
RECRUITING
Kurashikishi
University Hospital, Kyoto Prefectural Univ of Medicine
RECRUITING
Kyotoshi
Matsuyama Red Cross Hospital
RECRUITING
Matsuyama
Aichi Cancer Center Hospital Clinical Oncology
RECRUITING
Nagoya
National Hospital Organization Okayama Medical Center
RECRUITING
Okayama
Aiiku Hospital
RECRUITING
Sapporo
National Hospital Organization Hokkaido Cancer Center
RECRUITING
Sapporo
Kindai University Hospital
RECRUITING
Sayama
Tohoku University Hospital
NOT_YET_RECRUITING
Sendai
Yamagata University Hospital
RECRUITING
Yamagata
Kanagawa Cancer Center
RECRUITING
Yokohama
Yokohama Municipal Citizens Hospital
RECRUITING
Yokohama
Poland
Szpital Uniwersytecki Nr Im Dr Jana Biziela
COMPLETED
Bydgoszcz
Uniwersyteckie Centrum Kliniczne Klinika Hematologii I Transplantologii
COMPLETED
Gdansk
Pratia Onkologia Katowice
ACTIVE_NOT_RECRUITING
Katowice
Pratia McM Krakow
ACTIVE_NOT_RECRUITING
Krakow
Uniwersytecki Szpital Kliniczny W Poznaniu, Oddzial Hematologii I Transplantacji Szpiku
ACTIVE_NOT_RECRUITING
Poznan
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
ACTIVE_NOT_RECRUITING
Torun
Centralny Szpital Kliniczny Uck Wum
COMPLETED
Warsaw
Instytut Hematologii I Transfuzjologii
ACTIVE_NOT_RECRUITING
Warsaw
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie Hematology Unit
ACTIVE_NOT_RECRUITING
Warsaw
Portugal
Hospital de Braga
ACTIVE_NOT_RECRUITING
Braga
Instituto Portugues de Oncologia Do Porto Francisco Gentil, Epe
ACTIVE_NOT_RECRUITING
Porto
Unidade Local de Saude Gaia E Espinho
ACTIVE_NOT_RECRUITING
Vila Nova De Gaia Porto
Puerto Rico
Auxilio Mutuo Cancer Center
ACTIVE_NOT_RECRUITING
San Juan
Republic of Korea
Kyungpook National University Chilgok Hospital
ACTIVE_NOT_RECRUITING
Bukgu
Seoul National University Bundang Hospital
ACTIVE_NOT_RECRUITING
Bundanggu Seongnamsi
Inje University Busan Paik Hospital
ACTIVE_NOT_RECRUITING
Busanjingu
Samsung Medical Center
ACTIVE_NOT_RECRUITING
Gangnamgu
Chonnam National University Hwasun Hospital
ACTIVE_NOT_RECRUITING
Hwasungun
Gyeongsang National University Hospital
ACTIVE_NOT_RECRUITING
Jinju
The Catholic University of Korea, Seoul St Marys Hospital
ACTIVE_NOT_RECRUITING
Seochogu
Severance Hospital Yonsei University Health System
ACTIVE_NOT_RECRUITING
Seodaemungu
Dong A University Hospital
ACTIVE_NOT_RECRUITING
Seogu
Pusan National University Hospital
ACTIVE_NOT_RECRUITING
Seogu
Seoul National University Hospital
ACTIVE_NOT_RECRUITING
Seoul
Asan Medical Center
ACTIVE_NOT_RECRUITING
Songpagu
Soon Chun Hyang University Hospital Seoul
ACTIVE_NOT_RECRUITING
Yongsangu
Romania
Coltea Clinical Hospital
ACTIVE_NOT_RECRUITING
Bucharest
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ACTIVE_NOT_RECRUITING
Clujnapoca
Institutul Regional de Oncologie Iasi
ACTIVE_NOT_RECRUITING
Iași
Spitalul Clinic Judetean de Urgenta Bihor
ACTIVE_NOT_RECRUITING
Oradea
South Africa
Haemalife
ACTIVE_NOT_RECRUITING
Kuils River
Alberts Cellular Therapy
ACTIVE_NOT_RECRUITING
Pretoria
Spain
Ico Badalona
ACTIVE_NOT_RECRUITING
Badalona
Hospital Universitario de Burgos
ACTIVE_NOT_RECRUITING
Burgos
Hospital Universitario Puerta Del Mar
ACTIVE_NOT_RECRUITING
Cadiz
Hospital Universitario Virgen de Las Nieves
ACTIVE_NOT_RECRUITING
Granada
Institut Catala Doncologia Hospital Duran I Reynals
ACTIVE_NOT_RECRUITING
L'hospitalet De Llobregat
Complejo Asistencial Universitario de Leon
ACTIVE_NOT_RECRUITING
León
Clinica Universidad de Navarra
ACTIVE_NOT_RECRUITING
Madrid
Hospital de La Princesa
ACTIVE_NOT_RECRUITING
Madrid
Hospital Universitario Infanta Leonor
ACTIVE_NOT_RECRUITING
Madrid
Hospital Universitario Ramon Y Cajal
ACTIVE_NOT_RECRUITING
Madrid
H Puerta de Hierro Majadahonda
ACTIVE_NOT_RECRUITING
Majadahonda
Hospital Clinico Universitario Virgen de La Arrixaca
ACTIVE_NOT_RECRUITING
Murcia
Clinica Universidad de Navarra Pamplona
ACTIVE_NOT_RECRUITING
Pamplona
Hospital Universitario Quironsalud Madrid
ACTIVE_NOT_RECRUITING
Pozuelo De Alarcón
Hospital Universitario de Salamanca
ACTIVE_NOT_RECRUITING
Salamanca
Hospital Universitario Virgen Del Rocio
ACTIVE_NOT_RECRUITING
Seville
Hospital Universitari Mutua Terrassa
ACTIVE_NOT_RECRUITING
Terrassa
Switzerland
St Claraspital
ACTIVE_NOT_RECRUITING
Basel
Hfr Fribourg
ACTIVE_NOT_RECRUITING
Fribourg
Reseau Hospitalier Neuchatelois
ACTIVE_NOT_RECRUITING
La Chauxdefonds
Universitatsspital Zurich
ACTIVE_NOT_RECRUITING
Zurich
Turkey
Ankara University Medical Faculty
ACTIVE_NOT_RECRUITING
Ankara
Gazi University Medical School
ACTIVE_NOT_RECRUITING
Aociftlii
Bagcilar Medipol Mega Hospital
ACTIVE_NOT_RECRUITING
Istanbul
Kocaeli Universitesi Tip Fakultesi
ACTIVE_NOT_RECRUITING
Kocaeli
Vkv American Hospital
ACTIVE_NOT_RECRUITING
Tevikiye
United Kingdom
Beatson West of Scotland Cancer Centre
ACTIVE_NOT_RECRUITING
Glasgow
The Christie Hospital
ACTIVE_NOT_RECRUITING
Greater Manchester
Huddersfield Royal Infirmary
ACTIVE_NOT_RECRUITING
Huddersfield
Nhs Highland
COMPLETED
Inverness
The Leeds Teaching Hospitals Nhs Trust
ACTIVE_NOT_RECRUITING
Leeds
Barts Health Nhs Trust
COMPLETED
London
University College Hospital
ACTIVE_NOT_RECRUITING
London
Derriford Hospital
ACTIVE_NOT_RECRUITING
Plymouth
Southampton General Hospital
ACTIVE_NOT_RECRUITING
Southampton
Contact Information
Primary
Study Director BeiGene
clinicaltrials@beigene.com
1-877-828-5568
Time Frame
Start Date: 2022-03-10
Estimated Completion Date: 2030-06
Participants
Target number of participants: 780
Treatments
Experimental: Follicular Lymphoma Arm A: Zanubrutinib plus Obinutuzumab
Participants will receive zanubrutinib and Obinutuzumab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first.
Active_comparator: Follicular Lymphoma Arm B: Lenalidomide plus Rituximab
Participants will receive lenalidomide and rituximab.
Experimental: Marginal Zone Lymphoma Arm C: Zanubrutinib plus Rituximab
Participants will receive zanubrutinib and rituximab. Following the completion of the combination treatment, participants will continue receiving zanubrutinib monotherapy until confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination, whichever occurs first.
Active_comparator: Marginal Zone Lymphoma Arm D: Lenalidomide plus Rituximab
Participants will receive lenalidomide and rituximab.
Related Therapeutic Areas
Sponsors
Leads: BeiGene