Multicenter, Observational, Retrospective-prospective Study Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
Status: Recruiting
Location: See all (20) locations...
Study Type: Observational
SUMMARY
This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma or High-Grade B-cell Lymphoma
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 79
Healthy Volunteers: f
View:
• Diagnosis of nodal and extranodal Diffuse Large B Cell Lymphoma, High Grade B Cell Lymphomas (including low-grade transformed lymphomas; double and triple hit; 11q aberration; not otherwise specified) after 1st January 2019
• Presence of one MYC translocation or gain of copies (GCN: \> 3 copies in more than 30% of the nuclei) or amplification evaluated by FISH
• Availability of immunohistochemical analysis of CD10, Bcl6, MUM1, Bcl2, Myc, Ki67
• Have received curative treatment (e.g. R-CHOP, R DA EPOCH, intensified Burkitt like chemotherapies) as first-line therapy
• Histological material of adequate size and quality to perform histological review with any additional investigations (immunohistochemistry, FISH and other molecular analysis). A FFPE block must be provided for patient enrollment.
• Age between 18 and 79 years
Locations
Other Locations
Italy
A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia
RECRUITING
Alessandria
A.O.U. Ospedali Riuniti delle Marche - Clinica di Ematologia
RECRUITING
Ancona
I.R.C.C.S. Istituto Tumori Giovanni Paolo II - U.O.C. Ematologia