Non-Hodgkin Lymphoma Clinical Trials

• 1\. Subjects voluntarily participate in clinical research and sign informed consent.

• 2\. Subjects with CD19-negative relapsed or refractory B-cell lymphoma: a) failure to achieve CR after 6 cycles, or PR after 3 cycles, of first-line therapy, or achieve CR after first-line therapy but relapse within 12 months; b) achieve CR after systemic treatment, but are refractory or relapsed, and no plan to transplant, or prepare for transplantation but cannot meet transplantation criteria after second-line therapy; c) not achieve CR after at least two courses of second-line treatment (including autologous stem cell transplantation).

• 3\. Expected survival ≥ 3 months.

• 4\. BAFF-R expression are detected on tumor cells of subjects by flow cytometry or immunohistochemistry.

• 5\. ECOG score ≤ 2.

• 6\. Subjects with adequate organ functions prior to enrollment, meet the following laboratory values:

• Renal function: serum creatinine ≤ 1.5 × ULN or estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m²

• Hepatic function: Serum alanine aminotransferase (ALT) ≤ 5 × age-specific ULN and total bilirubin ≤ 2.0 mg/dL, except in subjects with Gilbert-Meulengracht syndrome. If total bilirubin ≤ 3.0 × ULN and direct bilirubin ≤ 1.5 × ULN, subjects with Gilbert-Meulengracht syndrome are included.

• Pulmonary reserve: ≤ Grade 1 dyspnea and oxygen saturation \>95% on room air.

• 7\. Stable hemodynamics and left ventricular ejection fraction (LVEF) ≥ 45 % assessed by echocardiography or multi-gated radionuclide angiography (MUGA).

• 8\. Adequate bone-marrow reserve without blood transfusion as defined by:

• Absolute neutrophil count (ANC) ≥ 1 x 10\^9/L.

• Absolute lymphocyte count (ALC) ≥ 0.1 x 10\^9/L.

• Platelets ≥ 50 x 10\^9/L.

• Hemoglobin \>80g/L.

• 9\. In the investigator's judgment, subjects' general condition and all biochemical values are either normal or sufficiently compensated to receive lymphodepletion and CAR-T cell therapy.