Learn About Nonalcoholic Steatohepatitis (NASH)

View Main Condition: Non-Alcoholic Fatty Liver Disease

What is the definition of Nonalcoholic Steatohepatitis (NASH)?
Nonalcoholic steatohepatitis is an advanced stage of nonalcoholic fatty liver disease that occurs in individuals who do not abuse alcohol. In nonalcoholic steatohepatitis, a buildup of fat in the liver causes it to become inflamed and damaged.
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What are the symptoms of Nonalcoholic Steatohepatitis (NASH)?
Early nonalcoholic steatohepatitis may not have any symptoms. Symptoms of nonalcoholic steatohepatitis that has progressed include weakness, fatigue, unexplained weight loss, and pain the upper right abdomen. Symptoms of severe nonalcoholic steatohepatitis may include symptoms of cirrhosis (scarring of the liver), such as constant itchiness, behavior changes, confusion, drowsiness, slurred speech, yellowing of the skin and whites of eyes, spider veins, easy bruising, bleeding, fluid in the abdomen, swelling of the legs and feet, an enlarged liver and/or spleen, enlarged esophageal veins, portal hypertension, and liver failure.
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What are the current treatments for Nonalcoholic Steatohepatitis (NASH)?
There is currently no cure for nonalcoholic steatohepatitis. Treatment for nonalcoholic steatohepatitis is focused on managing associated conditions that contribute to or worsen the disease, such as high cholesterol levels, diabetes, drinking alcohol, and obesity. Treatment for nonalcoholic steatohepatitis includes lowering cholesterol levels, losing weight, eating a healthy diet, controlling diabetes, stopping alcohol use, drinking coffee daily, and regular exercise.
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What are the latest Nonalcoholic Steatohepatitis (NASH) Clinical Trials?
Prevention of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanic Children

Summary: This is a 2 year clinical trial testing an intensive intervention to reduce dietary sugars as a means to prevent non-alcoholic fatty liver disease (NAFLD) in pre-pubertal Hispanic children.

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Identification of Clinical and Biological Factors Determining Disease Severity and Disease Progression in NAFLD: THE FRENCH NATIONAL NAFLD COHORT FRAMES (FRench pAtients With MEtabolic Steatosis)

Summary: The main objective of this cohort study is to determine genetic, clinical biologic and metabolic factors associated with patient heterogeneity in regards to severity of NAFLD at diagnosis as well as during the clinical course. at diagnosis, with the aim to better characterize patients of different severity and improve our understanding of clinical and histological heterogeneity at diagnosis during...

What are the Latest Advances for Nonalcoholic Steatohepatitis (NASH)?
Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Licogliflozin for nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a study.
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Effect of Probiotics Therapy on Nonalcoholic Fatty Liver Disease.