Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor; The DISCO-study
The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa. The study wants to investigate if the nasal mucosa application and measurements are feasible, what kind of possible complications such a measurement can cause, and if the measurements can be a surrogate marker for systemic carbon dioxide values.
∙ The subject must meet all of the following inclusion criteria at the time of enrolment:
∙ EITHER
• Patient are at risk of hypoventilation and thus carbon dioxide retention.
• Either
‣ Under evaluation for treatment with non-invasive ventilation and maybe Long term oxygen treatment due to chronic obstructive pulmonary disease or
⁃ Under evaluation for non-invasive ventilation support due to Obesity hypoventilation syndrome or due to a neuromuscular disorder.
• OR
• Healthy volunteers
• ALL subjects:
• Subject must be 18 years or older
• Subject must be able to give written informed consent